INT243864

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.22
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (DLG4) plasma membrane (DLG4) protein complex assembly (DLG4)
Anatomy Link Frequency
neuronal 1
photoreceptor 1
Murphy 1
embryonic kidney 1
synapses 1
DLG4 (Homo sapiens)
Pain Link Frequency Relevance Heat
GABAergic 101 97.28 Very High Very High Very High
Kinase C 1 81.88 Quite High
Glutamate receptor 22 77.04 Quite High
imagery 11 41.60 Quite Low
Pyramidal cell 2 31.48 Quite Low
ketamine 1 20.24 Low Low
Glutamate 7 16.96 Low Low
gABA 40 5.00 Very Low Very Low Very Low
Neurotransmitter 18 5.00 Very Low Very Low Very Low
Cannabinoid receptor 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 6 90.80 High High
Disease 24 50.00 Quite Low
Encephalitis 5 50.00 Quite Low
Epilepsy 20 35.92 Quite Low
Lifespan 27 26.80 Quite Low
Cancer 21 5.00 Very Low Very Low Very Low
Convulsion 19 5.00 Very Low Very Low Very Low
Neurological Disease 18 5.00 Very Low Very Low Very Low
Aging 17 5.00 Very Low Very Low Very Low
Lymphocytosis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Actually, neuronal overexpression of PSD-95 alone is sufficient to enhance the ratio between glutamatergic and GABAergic synapses (Prange et al., 2004).
Gene_expression (overexpression) of PSD-95 in neuronal associated with gabaergic
1) Confidence 0.34 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526001 Disease Relevance 0.07 Pain Relevance 0.12
As preformed scaffold protein packages are postsynaptic hotspots for the formation of excitatory synapses (Gerrow et al., 2006), it certainly is not surprising that overexpression of neuroligin-1 and the scaffolding protein PSD-95 enhances the E-I ratio of synaptic input (Prange et al., 2004).


Gene_expression (overexpression) of PSD-95 in synapses
2) Confidence 0.30 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526001 Disease Relevance 0.15 Pain Relevance 0.07
Human embryonic kidney 293 cells were transfected as above with NR2B and postsynaptic density 95 (PSD95, Open Biosystems, Image Consortium cDNA clones, USA) cDNA expression constructs and with the NR1-EGFP tagged expression construct in a ratio of 1:1:1.
Gene_expression (expression) of PSD95 in embryonic kidney
3) Confidence 0.20 Published 2010 Journal Brain Section Body Doc Link PMC2877907 Disease Relevance 0 Pain Relevance 0
This is very close to the larger measurement variability that we have found when quantifying the expression of inhibitory (gephyrin) versus excitatory (PSD-95) anchoring proteins in rat cortex (Pinto and Murphy, unpublished results).
Gene_expression (expression) of PSD-95 in Murphy
4) Confidence 0.09 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0 Pain Relevance 0.31
Immunostaining with PSD95 confirmed that there was GFP expression in the photoreceptor synaptic terminals (Figure 2F).
Gene_expression (expression) of PSD95 in photoreceptor
5) Confidence 0.08 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743804 Disease Relevance 0 Pain Relevance 0.04

General Comments

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