INT243875

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (DLG4) plasma membrane (DLG4) protein complex assembly (DLG4)
Anatomy Link Frequency
neuronal 2
synapses 2
DLG4 (Homo sapiens)
Pain Link Frequency Relevance Heat
GABAergic 32 97.28 Very High Very High Very High
Glutamate receptor 20 77.04 Quite High
Neurotransmitter 18 5.00 Very Low Very Low Very Low
hyperexcitability 8 5.00 Very Low Very Low Very Low
nMDA receptor 8 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
long-term potentiation 4 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Endocannabinoid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 6 90.80 High High
Disease 12 50.00 Quite Low
Epilepsy 14 35.92 Quite Low
Neurological Disease 14 5.00 Very Low Very Low Very Low
Intellectual Impairment 12 5.00 Very Low Very Low Very Low
Autism 10 5.00 Very Low Very Low Very Low
Schizophrenia 4 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Convulsion 4 5.00 Very Low Very Low Very Low
Encephalopathy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Actually, neuronal overexpression of PSD-95 alone is sufficient to enhance the ratio between glutamatergic and GABAergic synapses (Prange et al., 2004).
Positive_regulation (overexpression) of Gene_expression (overexpression) of PSD-95 in neuronal associated with gabaergic
1) Confidence 0.30 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526001 Disease Relevance 0.07 Pain Relevance 0.12
As preformed scaffold protein packages are postsynaptic hotspots for the formation of excitatory synapses (Gerrow et al., 2006), it certainly is not surprising that overexpression of neuroligin-1 and the scaffolding protein PSD-95 enhances the E-I ratio of synaptic input (Prange et al., 2004).


Positive_regulation (overexpression) of Gene_expression (overexpression) of PSD-95 in synapses
2) Confidence 0.27 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526001 Disease Relevance 0.15 Pain Relevance 0.07

General Comments

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