INT24388

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Context Info
Confidence 0.51
First Reported 1986
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 5.67
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRH, POMC) signal transduction (CRH, POMC) extracellular region (CRH, POMC)
small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
Anatomy Link Frequency
pituitary 4
plasma 2
CRH (Homo sapiens)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 8 99.92 Very High Very High Very High
Dynorphin 2 99.80 Very High Very High Very High
narcan 5 99.60 Very High Very High Very High
Opioid 5 99.44 Very High Very High Very High
antagonist 22 99.16 Very High Very High Very High
Catecholamine 19 98.96 Very High Very High Very High
dexamethasone 2 98.92 Very High Very High Very High
Neurotransmitter 8 88.72 High High
amygdala 4 88.08 High High
Clonidine 3 86.60 High High
Disease Link Frequency Relevance Heat
Cancer 24 99.60 Very High Very High Very High
Stress 240 99.56 Very High Very High Very High
Body Weight 5 95.16 Very High Very High Very High
Anxiety Disorder 24 86.04 High High
Nociception 1 83.12 Quite High
Pain 1 81.48 Quite High
Urological Neuroanatomy 4 79.48 Quite High
Syndrome 6 79.24 Quite High
Gastric Fistula 1 78.48 Quite High
Targeted Disruption 17 75.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Synthetic rat-human corticotropin releasing-factor (CRF), in doses between 10(-12) M and 10(-8) M, significantly stimulates the release of immunoreactive beta-endorphin and dynorphin-A from rat hypothalamic slices superfused in vitro.
CRF Positive_regulation (stimulates) of Localization (release) of beta-endorphin associated with dynorphin
1) Confidence 0.51 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2893273 Disease Relevance 0 Pain Relevance 0.29
These results show that modulation of peripheral plasma catecholamine levels within physiological limits does not affect CRF-stimulated release of ACTH or the adrenal response in normal man.
CRF Positive_regulation (stimulated) of Localization (release) of ACTH in plasma associated with catecholamine
2) Confidence 0.50 Published 1986 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3024878 Disease Relevance 0 Pain Relevance 0.62
In dispersed monolayer culture, CRF failed to elicit ACTH release from the tumor cells, but dexamethasone caused a paradoxical increase in ACTH secretion in vitro.
CRF Neg (failed) Positive_regulation (elicit) of Localization (release) of ACTH associated with cancer and dexamethasone
3) Confidence 0.26 Published 1988 Journal Horm. Metab. Res. Section Abstract Doc Link 2456259 Disease Relevance 0.75 Pain Relevance 0.18
Corticotropin-releasing hormone (CRH) travels in the hypothalamo-hypophyseal portal circulation to the pituitary (perhaps within 10 s) to stimulate the release of ACTH, enkephalins, and endorphins [11, 24].
CRH Positive_regulation (stimulate) of Localization (release) of ACTH in pituitary associated with enkephalin
4) Confidence 0.14 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 1.69 Pain Relevance 0.82
Corticotropin-releasing hormone (CRH) travels in the hypothalamo-hypophyseal portal circulation to the pituitary (perhaps within 10 s) to stimulate the release of ACTH, enkephalins, and endorphins [11, 24].
Corticotropin-releasing hormone Positive_regulation (stimulate) of Localization (release) of ACTH in pituitary associated with enkephalin
5) Confidence 0.14 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 1.82 Pain Relevance 0.82
Corticotropin-releasing factor (CRF) is thought to be an endogenous mediator of adrenocorticotropic hormone release following stress.
Corticotropin-releasing factor Positive_regulation (mediator) of Localization (release) of adrenocorticotropic hormone associated with stress
6) Confidence 0.09 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3544874 Disease Relevance 0.25 Pain Relevance 0.04
Ghrelin also induces the anorexigenic hypothalamic CRH gene [567], which normally stimulates ACTH release.
CRH Positive_regulation (stimulates) of Localization (release) of ACTH
7) Confidence 0.06 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 1.06 Pain Relevance 0.15
Potentiation of the hCRF-induced release of ACTH in man by an opioid antagonist.
hCRF Positive_regulation (induced) of Localization (release) of ACTH associated with antagonist, narcan and opioid
8) Confidence 0.01 Published 1987 Journal Klin. Wochenschr. Section Title Doc Link 3037181 Disease Relevance 0.10 Pain Relevance 0.42

General Comments

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