INT243927

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 12
Disease Relevance 1.10
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg1) plasma membrane (Gabrg1)
Anatomy Link Frequency
brain 1
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 336 100.00 Very High Very High Very High
Action potential 60 98.48 Very High Very High Very High
Kinase C 120 97.60 Very High Very High Very High
Neurotransmitter 108 95.52 Very High Very High Very High
Nucleus accumbens 60 95.12 Very High Very High Very High
GABAergic 348 94.56 High High
Hippocampus 72 94.48 High High
agonist 48 93.88 High High
depression 96 91.52 High High
Dopamine 36 86.96 High High
Disease Link Frequency Relevance Heat
Depression 96 91.52 High High
Premenstrual Syndrome 12 86.16 High High
Anxiety Disorder 48 59.48 Quite High
Targeted Disruption 84 5.28 Low Low
Generalized Anxiety Disorder 24 5.00 Very Low Very Low Very Low
Stress 24 5.00 Very Low Very Low Very Low
Epilepsy 24 5.00 Very Low Very Low Very Low
Respiratory Failure 12 5.00 Very Low Very Low Very Low
Necrosis 12 5.00 Very Low Very Low Very Low
Adhesions 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phosphorylated PRIP-1 releases PP1A that results in dephosphorylation of the GABAA receptor beta subunit and a dynamic regulation of synaptic efficiency.
Phosphorylation (dephosphorylation) of GABAA receptor
1) Confidence 0.52 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.14 Pain Relevance 0.14
Kinases not only modulate channel function by phosphorylating the GABAA receptor directly, but also mediate the effect of extracellular stimuli like growth factors or the crosstalk with other neurotransmitter systems on the trafficking of the receptor.
Phosphorylation (phosphorylating) of GABAA receptor associated with neurotransmitter
2) Confidence 0.52 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.09
Protein phosphatase 1alpha (PP1A) regulates the phosphorylation of GABAA receptor beta subunits through PKA.
Phosphorylation (phosphorylation) of GABAA receptor
3) Confidence 0.52 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.18 Pain Relevance 0.14
PKA phosphorylates GABAA receptors but also the GABAA receptor associated protein PRIP-1 (Phospholipase C-related inactive protein type I) that under basal conditions binds PP1A and keeps it in an inactive form.
Phosphorylation (phosphorylates) of GABAA
4) Confidence 0.52 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.16 Pain Relevance 0.13
Similarly, brain-derived neurotrophic factor (BDNF) produces short-term and long-term effects via modulation of the phosphorylation state of GABAA receptors.
Phosphorylation (phosphorylation) of GABAA in brain
5) Confidence 0.52 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.11 Pain Relevance 0.13
PKA phosphorylates GABAA receptors but also the GABAA receptor associated protein PRIP-1 (Phospholipase C-related inactive protein type I) that under basal conditions binds PP1A and keeps it in an inactive form.
Phosphorylation (phosphorylates) of GABAA receptor
6) Confidence 0.52 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.16 Pain Relevance 0.13
PP-1 can also directly dephosphorylate the GABAA receptor.
Phosphorylation (dephosphorylate) of GABAA receptor
7) Confidence 0.51 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.10
PKA negatively regulates the endocytosis of the GABAA receptor via phosphorylation of an atypical binding motif for the clathrin AP-2 adaptor complex (see below).
Phosphorylation (phosphorylation) of GABAA receptor
8) Confidence 0.51 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.56
The authors inactivated action potentials by TTX to avoid the activation of peri-and extrasynaptic receptors through GABA spillover and recorded mIPSCs and evoked IPSCs before, during and after an 8?
Phosphorylation (spillover) of GABA associated with action potential and gaba
9) Confidence 0.45 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.09 Pain Relevance 0.28
Kinases known to phosphorylate GABAA receptors include the cAMP-dependent protein kinase (PKA), Protein kinase C (PKC), Ca2+/calmodulin dependent kinase II (CaMK-II), Protein kinase B (Akt) and tyrosine kinases of the Src family.
Phosphorylation (phosphorylate) of GABAA associated with kinase c
10) Confidence 0.40 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.15 Pain Relevance 0.20
In vitro phosphorylation sites of the GABAA receptor by CaMK-II are beta1-serine 384 and 408, 409, beta2-serine 410, beta3-serine 383 and 408, 409, gamma2S/L-serine 348 and threonine 350, gamma2L-serine 343 (Machu et al., 1993; McDonald and Moss, 1994, 1997).
Phosphorylation (phosphorylation) of GABAA receptor
11) Confidence 0.40 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.05 Pain Relevance 0.40
In vitro phosphorylation sites of the GABAA receptor by CaMK-II are beta1-serine 384 and 408, 409, beta2-serine 410, beta3-serine 383 and 408, 409, gamma2S/L-serine 348 and threonine 350, gamma2L-serine 343 (Machu et al., 1993; McDonald and Moss, 1994, 1997).
Phosphorylation (phosphorylation) of GABAA receptor
12) Confidence 0.40 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.05 Pain Relevance 0.40

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