INT243929

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.27
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Vasp) cytoskeleton (Vasp) cytoplasm (Vasp)
Vasp (Mus musculus)
Pain Link Frequency Relevance Heat
depression 8 83.36 Quite High
amygdala 1 77.56 Quite High
Hippocampus 6 76.40 Quite High
ischemia 16 76.00 Quite High
GABAergic 29 50.00 Quite Low
gABA 28 5.00 Very Low Very Low Very Low
Kinase C 10 5.00 Very Low Very Low Very Low
Neurotransmitter 9 5.00 Very Low Very Low Very Low
Glutamate 8 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 42 99.12 Very High Very High Very High
Adhesions 13 98.60 Very High Very High Very High
Pressure And Volume Under Development 56 98.20 Very High Very High Very High
Hypoxia 16 95.92 Very High Very High Very High
Anxiety Disorder 4 90.08 High High
Depression 8 83.36 Quite High
Brain Hemorrhage 12 77.20 Quite High
Targeted Disruption 9 71.92 Quite High
Middle Cerebral Artery Infarction 4 69.52 Quite High
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An indirect interaction of gephyrin with the actin cytoskeleton is mediated by the actin binding proteins profilin I and IIA and by the microfilament adaptors of the Mena/VASP family that also interact with each other and regulate microfilament dynamics (Lambrechts et al., 2000).
VASP Binding (interact) of
1) Confidence 0.47 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.25 Pain Relevance 0.12
Vasodilator-stimulated phosphoprotein (VASP) is an important regulator of actin dynamics and stabilizes endothelial barriers through interaction with cell-cell contacts and focal adhesion sites.
VASP Binding (interaction) of associated with adhesions
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2997079 Disease Relevance 1.01 Pain Relevance 0.04
Vasodilator-stimulated phosphoprotein (VASP) is an important regulator of actin dynamics and stabilizes endothelial barriers through interaction with cell-cell contacts and focal adhesion sites.
Vasodilator-stimulated phosphoprotein Binding (interaction) of associated with adhesions
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2997079 Disease Relevance 1.01 Pain Relevance 0.04

General Comments

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