INT243933

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Camk2d) plasma membrane (Camk2d) nucleus (Camk2d)
kinase activity (Camk2d) cytoplasm (Camk2d)
Camk2d (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 10 89.64 High High
GABAergic 58 89.08 High High
agonist 8 88.40 High High
Dopamine 6 81.48 Quite High
Serotonin 2 71.64 Quite High
Kinase C 20 70.32 Quite High
Endocannabinoid 6 57.04 Quite High
Glutamate receptor 12 52.84 Quite High
gABA 56 44.56 Quite Low
Glutamate 16 31.44 Quite Low
Disease Link Frequency Relevance Heat
Depression 16 22.56 Low Low
Targeted Disruption 14 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Epilepsy 4 5.00 Very Low Very Low Very Low
Respiratory Failure 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another recent study does not entirely support the hypothesis on the role of PP-1, as they have some evidence that CaMK-II modulation of GABAA receptors critically requires Ca2+/CaM binding to CaMK-II but not autophosphorylation (C.
Gene_expression (modulation) of CaMK-II
1) Confidence 0.10 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.03
No adapter protein is known for CaMK-II, although the enzyme can also be pulled down with the GABAA receptor (McAinsh, Tretter, Moss unpublished observations).
Neg (No) Gene_expression (known) of CaMK-II
2) Confidence 0.10 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.53

General Comments

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