INT243949

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.29
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Gphn) plasma membrane (Gphn) cytoskeleton (Gphn)
intracellular (Gphn) cytoplasm (Gphn)
Anatomy Link Frequency
neurons 1
vesicles 1
Gphn (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 12 97.44 Very High Very High Very High
gABA 56 92.84 High High
Neurotransmitter 40 92.64 High High
Spinal cord 51 74.16 Quite High
GABAergic 46 65.60 Quite High
agonist 8 52.24 Quite High
nMDA receptor 7 51.48 Quite High
interneuron 4 48.40 Quite Low
medulla 8 45.28 Quite Low
Lasting pain 1 22.76 Low Low
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 3 97.76 Very High Very High Very High
Adhesions 1 75.40 Quite High
Targeted Disruption 16 65.04 Quite High
Respiratory Failure 1 55.28 Quite High
Nervous System Injury 1 34.20 Quite Low
Stress 2 29.68 Quite Low
Pain 4 22.76 Low Low
Epilepsy 2 21.40 Low Low
Ganglion Cysts 10 5.00 Very Low Very Low Very Low
Depression 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Fig. 2c, scFvGeph-2/scFvGeph-9 antibodies were able to co-immunoprecipitate gephyrin, suggesting that they interacted with gephyrin intracellularly.
Positive_regulation (immunoprecipitate) of gephyrin
1) Confidence 0.41 Published 2007 Journal J Mol Neurosci Section Body Doc Link PMC2758390 Disease Relevance 0 Pain Relevance 0
Experiments using the GlyR antagonist strychnine and L-type Ca+2 blockers on spinal neurons suggest that GlyR activation leads to Ca+2 transients that in turn cause accumulation of the anchoring protein Gephyrin and GlyR.
Positive_regulation (accumulation) of Gephyrin in neurons associated with antagonist
2) Confidence 0.12 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0 Pain Relevance 0.43
Mixed cultures of neurons and transfected fibroblast cells revealed that expression of beta-neurexin induces clusters of the postsynaptic marker gephyrin and vice versa, the expression of neuroligins recruits GAD-65 positive vesicles in the presynaptic terminals (Graf et al., 2004).
Positive_regulation (induces) of gephyrin in vesicles associated with generalized anxiety disorder
3) Confidence 0.11 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.29 Pain Relevance 0.09

General Comments

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