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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.33
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Ppp1ca) nucleus (Ppp1ca) cell cycle (Ppp1ca)
carbohydrate metabolic process (Ppp1ca) cell division (Ppp1ca) cytoplasm (Ppp1ca)
Ppp1ca (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 24 91.84 High High
Dopamine 26 86.12 High High
amygdala 5 85.36 High High
Hippocampus 15 77.28 Quite High
depression 9 74.00 Quite High
addiction 35 65.32 Quite High
antagonist 2 53.16 Quite High
GABAergic 33 50.00 Quite Low
Kinase C 10 48.16 Quite Low
cocaine 11 40.24 Quite Low
Disease Link Frequency Relevance Heat
Depression 9 74.00 Quite High
Targeted Disruption 31 70.00 Quite High
Anxiety Disorder 6 55.04 Quite High
Apoptosis 5 45.60 Quite Low
Frailty 2 29.04 Quite Low
Stress 3 13.16 Low Low
Drug Dependence 7 5.00 Very Low Very Low Very Low
Cold Sores 7 5.00 Very Low Very Low Very Low
Recurrence 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the one hand, the phosphorylation on Thr34 by protein kinase A (PKA) converts DARPP-32 into a selective inhibitor of serine/threonine protein phosphatase-1 (PP-1), thereby enhancing phosphorylation of proteins targeted by PP-1.
Phosphorylation (phosphorylation) of PP-1
1) Confidence 0.11 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.13 Pain Relevance 0.13
Indeed, in its activated state as pThr34-DARPP-32, it becomes a robust inhibitor of protein phosphatase 1 (PP-1), a substrate responsible for de-phosphorylation of numerous cellular targets.
Phosphorylation (phosphorylation) of PP-1
2) Confidence 0.08 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.06 Pain Relevance 0.27
The phosphorylated PRIP-1 releases PP1A that results in dephosphorylation of the GABAA receptor beta subunit and a dynamic regulation of synaptic efficiency.
Phosphorylation (phosphorylated) of PP1A
3) Confidence 0.01 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.15 Pain Relevance 0.11

General Comments

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