INT243956

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 0.94
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Gphn) plasma membrane (Gphn) cytoskeleton (Gphn)
intracellular (Gphn) cytoplasm (Gphn)
Anatomy Link Frequency
neuronal 1
neurons 1
spinal cord 1
amygdala 1
synapses 1
Gphn (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 17 98.56 Very High Very High Very High
Spinal cord 12 98.00 Very High Very High Very High
amygdala 2 97.28 Very High Very High Very High
depression 16 83.12 Quite High
GABAergic 58 69.60 Quite High
antagonist 35 41.04 Quite Low
tetrodotoxin 5 35.72 Quite Low
Glutamate receptor 22 32.00 Quite Low
medulla 4 18.32 Low Low
gABA 56 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 49 99.28 Very High Very High Very High
Depression 16 83.12 Quite High
Death 5 80.72 Quite High
Anxiety Disorder 8 69.44 Quite High
Neurologic Manifestations 5 60.80 Quite High
Disease 7 46.96 Quite Low
Respiratory Failure 2 13.72 Low Low
Sprains And Strains 15 9.84 Low Low
Generalized Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Note that the nuclear accumulation of scFv-Gephyrin-NLS was associated with a marked reduction of both gephyrin (scFv + Gephyrin in A) and glycine receptor clusters (scFv + GlyRs in B).
Negative_regulation (reduction) of gephyrin
1) Confidence 0.35 Published 2007 Journal J Mol Neurosci Section Body Doc Link PMC2758390 Disease Relevance 0 Pain Relevance 0
To exploit the intrabodies-based retargeting scheme for depleting endogenous gephyrin from inhibitory synapses, the linker or intervening region of gephyrin molecule was used for the two-hybrid selection method.
Negative_regulation (depleting) of gephyrin in synapses
2) Confidence 0.35 Published 2007 Journal J Mol Neurosci Section Body Doc Link PMC2758390 Disease Relevance 0.18 Pain Relevance 0
In the present study, a nuclear localization signal (NLS)-targeted intrabody for the removal of endogenous gephyrin from inhibitory receptor clusters in cultured hippocampal neurons has been developed.
Negative_regulation (removal) of gephyrin in neurons
3) Confidence 0.35 Published 2007 Journal J Mol Neurosci Section Body Doc Link PMC2758390 Disease Relevance 0 Pain Relevance 0
Note that the nuclear accumulation of scFv-Gephyrin-NLS was associated with a marked reduction of both gephyrin (scFv + Gephyrin in A) and glycine receptor clusters (scFv + GlyRs in B).
Negative_regulation (reduction) of Gephyrin
4) Confidence 0.31 Published 2007 Journal J Mol Neurosci Section Body Doc Link PMC2758390 Disease Relevance 0 Pain Relevance 0
The critical contribution of gephyrin to the postsynaptic localization of GlyRs in the spinal cord has been elegantly demonstrated by gene ablation experiments (Feng et al. 1998).
Negative_regulation (contribution) of gephyrin in spinal cord associated with spinal cord
5) Confidence 0.30 Published 2007 Journal J Mol Neurosci Section Body Doc Link PMC2758390 Disease Relevance 0.32 Pain Relevance 0.08
Collybistin knock out mice exhibit a region specific loss of postsynaptic gephyrin and GABAA receptor clusters in the hippocampus and the basolateral amygdala.
Negative_regulation (loss) of gephyrin in amygdala associated with targeted disruption, hippocampus and amygdala
6) Confidence 0.15 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.25 Pain Relevance 0.17
The synaptic formation of gephyrin and GABAA receptor clusters are mutually dependent on each other: neuronal cultures from gephyrin knock out mice show an extensive loss of alpha2 and gamma2 containing GABAA receptor clusters and vice versa in GABAA receptor gamma2 subunit knock out mice the synaptic gephyrin clusters are absent and the remaining alpha-beta containing receptors are diffusely distributed on the cell surface (Craig et al., 1996; Essrich et al., 1998; G√ľnther et al., 1995).
Negative_regulation (formation) of gephyrin in neuronal associated with targeted disruption
7) Confidence 0.11 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.19 Pain Relevance 0.10

General Comments

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