INT243959

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.43
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabarap) Golgi apparatus (Gabarap) plasma membrane (Gabarap)
cytoskeleton (Gabarap) lysosome (Gabarap) cytoplasm (Gabarap)
Anatomy Link Frequency
synapses 1
Gabarap (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 8 83.28 Quite High
Inflammation 11 77.92 Quite High
GABAergic 61 76.08 Quite High
Spinal cord 2 74.28 Quite High
gABA 58 70.80 Quite High
Pyramidal cell 32 70.00 Quite High
chemokine 4 67.76 Quite High
Glutamate 16 57.68 Quite High
nMDA receptor 12 36.96 Quite Low
depression 16 28.32 Quite Low
Disease Link Frequency Relevance Heat
Status Epilepticus 57 85.36 High High
INFLAMMATION 12 77.92 Quite High
Targeted Disruption 15 72.24 Quite High
Gliosis 4 45.36 Quite Low
Depression 16 28.32 Quite Low
Respiratory Failure 2 23.40 Low Low
Epilepsy 20 5.00 Very Low Very Low Very Low
Convulsion 18 5.00 Very Low Very Low Very Low
Apoptosis 10 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2.13) gene, and an up-regulation of the GABAA receptor-associated protein (GABARAP; +1.81) gene.
Positive_regulation (up-regulation) of GABAA receptor-associated protein
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.30 Pain Relevance 0.11
One hot candidate would have been the 14kD protein GABARAP, that interacts with the GABAA receptor gamma2 subunit as well as with gephyrin, but confocal microscopy as well as electronmicroscopic studies revealed, that only minute amounts of GABARAP are found in the synapses, while the majority is located in intracellular compartments implying a role of GABARAP in trafficking rather than in synaptic clustering.
Positive_regulation (role) of GABARAP in synapses
2) Confidence 0.21 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.13 Pain Relevance 0.11
Rebound potentiation seems to be a far more complex process, as several other factors, like a structural change of GABARAP and the involvement of tyrosine kinases is currently discussed (Kawaguchi and Hirano, 2006, 2007)
Positive_regulation (change) of GABARAP
3) Confidence 0.21 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.20

General Comments

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