INT243962

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.13
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Gphn) plasma membrane (Gphn) cytoskeleton (Gphn)
intracellular (Gphn) cytoplasm (Gphn)
Anatomy Link Frequency
boutons 2
Gphn (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 58 97.08 Very High Very High Very High
imagery 4 59.56 Quite High
Glutamate receptor 12 47.60 Quite Low
depression 16 30.12 Quite Low
Hippocampus 12 27.44 Quite Low
gABA 56 25.08 Quite Low
amygdala 2 24.88 Low Low
Spinal cord 2 23.08 Low Low
Action potential 10 21.88 Low Low
Kinase C 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 14 69.16 Quite High
Depression 16 30.12 Quite Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Epilepsy 4 5.00 Very Low Very Low Very Low
Respiratory Failure 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A way of communication between presynaptic inputs and postsynaptic organization has been shown by the fact, that reducing gephyrin expression for instance with small hairpin RNAs results in a reduction of opposite GABAergic presynaptic boutons (Yu et al., 2007).
Negative_regulation (reducing) of Gene_expression (expression) of gephyrin in boutons associated with gabaergic
1) Confidence 0.13 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.13 Pain Relevance 0.05
Jacob et al. (2005) used RNA interference (RNAi) to reduce gephyrin expression and found, that this does not affect total cell surface receptor expression, but reduces receptor cluster numbers.
Negative_regulation (reduce) of Gene_expression (expression) of gephyrin
2) Confidence 0.11 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox