INT243974

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.36
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tfap2a) Golgi apparatus (Tfap2a) nucleus (Tfap2a)
DNA binding (Tfap2a) transcription factor binding (Tfap2a) cytoplasm (Tfap2a)
Anatomy Link Frequency
adipocyte 1
Tfap2a (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 5 94.64 High High
Kinase C 50 94.48 High High
Nucleus accumbens 25 94.24 High High
Glutamate receptor 30 92.84 High High
GABAergic 145 92.40 High High
Dopamine 15 91.24 High High
Neurotransmitter 45 90.88 High High
cytokine 10 85.12 High High
Hippocampus 32 68.64 Quite High
depression 40 66.36 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 10 96.60 Very High Very High Very High
Obesity 10 88.44 High High
Cancer 8 84.40 Quite High
Necrosis 6 83.92 Quite High
Hypoxia 14 81.68 Quite High
Disease 163 75.68 Quite High
Depression 40 66.36 Quite High
Targeted Disruption 69 65.16 Quite High
Death 8 56.96 Quite High
Hematological Disease 6 53.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast the mRNA for the adipocyte-specific fatty acids binding protein aP2 was increased.
aP2 Binding (binding) of in adipocyte
1) Confidence 0.18 Published 2010 Journal PPAR Research Section Body Doc Link PMC2896849 Disease Relevance 0.49 Pain Relevance 0
It also contains a variety of transcription factor binding sites, including those for Sp1, GATA-1, AP1, AP2, CREB, estrogen and glucocorticoid receptors, NF?
AP2 Binding (estrogen) of
2) Confidence 0.11 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.56 Pain Relevance 0
An adaptor protein (AP-2 complex) binds the receptor and facilitates the interaction with clathrin.
AP-2 Binding (binds) of
3) Confidence 0.04 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.07 Pain Relevance 0.13
The GABAA receptor contains several AP-2 binding motifs.
AP-2 Binding (binding) of
4) Confidence 0.03 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.08
Activation of the D3 receptor resulted in a reduction of GABAA receptor currents, that was dependent on PKA activity, dynamin and an atypical AP-2 binding motif on the beta3 subunit with a critical PKA site, that needs to be dephosphorylated to mediate the effect (Chen et al., 2006; Kittler et al., 2005).
AP-2 Binding (binding) of
5) Confidence 0.03 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.23 Pain Relevance 0.48
Binding of the AP-2 complex to a dileucine motif within the beta 2 subunit is involved in the process.
AP-2 Binding (Binding) of
6) Confidence 0.03 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.12
Binding of the AP-2 complex to a dileucine motif within the beta 2 subunit is involved in the process.
AP-2 Binding (complex) of
7) Confidence 0.03 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.12

General Comments

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