INT243978

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2r1a) chromosome segregation (Ppp2r1a) chromosome (Ppp2r1a)
cytoplasm (Ppp2r1a)
Anatomy Link Frequency
PP2A 1
Ppp2r1a (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 25 97.84 Very High Very High Very High
monoamine 1 87.76 High High
gABA 30 83.84 Quite High
GABA receptor 2 66.24 Quite High
Dopamine 34 50.00 Quite Low
GABAergic 29 50.00 Quite Low
Hippocampus 6 44.96 Quite Low
depression 8 41.68 Quite Low
Neurotransmitter 11 5.00 Very Low Very Low Very Low
Glutamate 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 8 41.68 Quite Low
Obesity 2 25.44 Quite Low
Disease 4 16.40 Low Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of serines 408/409 then increases binding affinity and recruitment of PP2A that dephosphorylates the receptor and subsequently reduces the efficacy of synaptic inhibition in the longterm (Jovanovic et al., 2004).


PP2A Binding (recruitment) of
1) Confidence 0.08 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.08
In the case of SERT, the interaction with PP2A was dynamically regulated by phosphatase inhibition, PKC activation and transporter substrates.
PP2A Binding (interaction) of in PP2A associated with kinase c
2) Confidence 0.03 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.28

General Comments

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