INT244020

Context Info Confidence 0.10 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

transport (Gabrg1) mitochondrion (Ppp1cc) carbohydrate metabolic process (Ppp1cc) protein complex (Ppp1cc) cytoplasm (Ppp1cc) chromosome (Ppp1cc)

Ppp1cc (Mus musculus) Gabrg1 (Mus musculus)

Pain Link Frequency Relevance Heat GABAergic 29 50.00 imagery 2 14.56 gABA 28 5.00 Kinase C 10 5.00 Neurotransmitter 9 5.00 depression 8 5.00 Glutamate 8 5.00 Glutamate receptor 6 5.00 Hippocampus 6 5.00 Nucleus accumbens 5 5.00

Disease Link Frequency Relevance Heat Bardet-biedl Syndrome 1 17.56 Depression 8 5.00 Targeted Disruption 7 5.00 Anxiety Disorder 4 5.00 Generalized Anxiety Disorder 2 5.00 Stress 2 5.00 Epilepsy 2 5.00 Respiratory Failure 1 5.00 Necrosis 1 5.00 Adhesions 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The group of Hirano suggests, that PP-1 reduces GABAA receptor function by controlling the autophosphorylation of CaMKII (Sugiyama et al., 2008).

PP-1 Negative_regulation (reduces) of GABAA receptor

1) Confidence 0.10 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0

General Comments

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