INT244025

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.18
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prkaca, Gabrg1) transport (Gabrg1) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) protein complex (Prkaca) cytoplasm (Prkaca)
Prkaca (Mus musculus)
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 10 97.04 Very High Very High Very High
GABAergic 58 96.48 Very High Very High Very High
agonist 8 95.80 Very High Very High Very High
Hippocampus 12 95.04 Very High Very High Very High
depression 16 91.76 High High
Dopamine 6 88.88 High High
Serotonin 2 79.04 Quite High
Kinase C 20 77.72 Quite High
Glutamate receptor 12 60.24 Quite High
gABA 56 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 16 91.76 High High
Targeted Disruption 14 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Epilepsy 4 5.00 Very Low Very Low Very Low
Respiratory Failure 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein phosphatase 1alpha (PP1A) regulates the phosphorylation of GABAA receptor beta subunits through PKA.
PKA Regulation (regulates) of Phosphorylation (phosphorylation) of GABAA receptor
1) Confidence 0.08 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.18 Pain Relevance 0.14
PKA negatively regulates the endocytosis of the GABAA receptor via phosphorylation of an atypical binding motif for the clathrin AP-2 adaptor complex (see below).
PKA Regulation (regulates) of Phosphorylation (phosphorylation) of GABAA receptor
2) Confidence 0.08 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.58

General Comments

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