INT244035

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prkaca, Tfap2a) cytoplasm (Prkaca, Tfap2a) nucleus (Prkaca, Tfap2a)
mitochondrion (Prkaca) DNA binding (Tfap2a) protein complex (Prkaca)
Prkaca (Mus musculus)
Tfap2a (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 5 95.76 Very High Very High Very High
GABAergic 29 93.92 High High
Dopamine 3 92.76 High High
Neurotransmitter 9 90.64 High High
Kinase C 10 88.40 High High
cytokine 1 85.60 High High
Hippocampus 6 69.12 Quite High
Action potential 5 58.32 Quite High
Glutamate receptor 6 51.36 Quite High
gABA 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 1 84.88 Quite High
Necrosis 1 84.40 Quite High
Targeted Disruption 7 66.68 Quite High
Depression 8 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Respiratory Failure 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the D3 receptor resulted in a reduction of GABAA receptor currents, that was dependent on PKA activity, dynamin and an atypical AP-2 binding motif on the beta3 subunit with a critical PKA site, that needs to be dephosphorylated to mediate the effect (Chen et al., 2006; Kittler et al., 2005).
PKA Binding (motif) of AP-2
1) Confidence 0.01 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.24 Pain Relevance 0.49

General Comments

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