INT244038

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.24
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg2, Gabarap) plasma membrane (Gabrg2, Gabarap) cytoplasm (Gabrg2, Gabarap)
Golgi apparatus (Gabarap) cytoskeleton (Gabarap) lysosome (Gabarap)
Anatomy Link Frequency
synapses 1
Gabrg2 (Mus musculus)
Gabarap (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 2 96.84 Very High Very High Very High
GABAergic 58 87.92 High High
Spinal cord 2 86.12 High High
medulla 4 39.84 Quite Low
GABA receptor 4 37.56 Quite Low
Kinase C 20 14.52 Low Low
gABA 56 5.00 Very Low Very Low Very Low
Neurotransmitter 18 5.00 Very Low Very Low Very Low
depression 16 5.00 Very Low Very Low Very Low
Glutamate 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 14 83.64 Quite High
Starvation 2 51.36 Quite High
Apoptosis 2 50.16 Quite High
Respiratory Failure 2 35.24 Quite Low
Generalized Anxiety Disorder 4 14.48 Low Low
Depression 16 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Epilepsy 4 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One hot candidate would have been the 14kD protein GABARAP, that interacts with the GABAA receptor gamma2 subunit as well as with gephyrin, but confocal microscopy as well as electronmicroscopic studies revealed, that only minute amounts of GABARAP are found in the synapses, while the majority is located in intracellular compartments implying a role of GABARAP in trafficking rather than in synaptic clustering.
gamma2 Binding (interacts) of GABARAP in synapses
1) Confidence 0.08 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.05 Pain Relevance 0.13
Another family member is GEC-1, that like GABARAP binds the gamma2 subunit, tubulin and NSF and plays an important role in surface expression of kappa-opioid receptors (Chen et al., 2006).
gamma2 Binding (binds) of GABARAP associated with kappa opioid receptor
2) Confidence 0.06 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.19 Pain Relevance 0.05

General Comments

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