INT24407

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Context Info
Confidence 0.25
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.81
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
striatum 3
substantia nigra 1
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 51 100.00 Very High Very High Very High
Substantia nigra 6 98.52 Very High Very High Very High
Morphine 12 97.16 Very High Very High Very High
cerebral cortex 37 97.04 Very High Very High Very High
dopamine receptor 14 75.00 Quite High
Inflammation 1 63.36 Quite High
Neurotransmitter 11 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 90 100.00 Very High Very High Very High
Cognitive Disorder 11 76.32 Quite High
INFLAMMATION 1 63.36 Quite High
Stress 9 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Hyperglycemia 4 5.00 Very Low Very Low Very Low
Cerebellar Diseases 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative autoradiography of receptor binding sites revealed only a significant reduction of [3H]SCH-23390 and [3H]spiperone binding to D-1 and D-2 sites, respectively, in the substantia nigra pars compacta of morphine-treated rats. 5-HT and 5-HIAA levels remained unchanged in the substantia nigra and striatum, but the nigral levels of DA and DOPAC and the levels of DOPAC in the striatum were reduced significantly by morphine treatment.
Negative_regulation (reduction) of D-1 Binding (binding) of in striatum associated with dopamine, substantia nigra and morphine
1) Confidence 0.25 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2456939 Disease Relevance 0 Pain Relevance 0.86
We report that curcumin supplementation reduces diabetes induced alteration of dopamine D1, D2 receptors, transcription factor CREB and phospholipase C to near control.
Negative_regulation (reduces) of dopamine D1 Binding (alteration) of associated with dopamine and diabetes mellitus
2) Confidence 0.21 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2890658 Disease Relevance 0.81 Pain Relevance 0.45
Quantitative autoradiography of receptor binding sites revealed only a significant reduction of [3H]SCH-23390 and [3H]spiperone binding to D-1 and D-2 sites, respectively, in the substantia nigra pars compacta of morphine-treated rats. 5-HT and 5-HIAA levels remained unchanged in the substantia nigra and striatum, but the nigral levels of DA and DOPAC and the levels of DOPAC in the striatum were reduced significantly by morphine treatment.
Negative_regulation (reduction) of D-1 in substantia nigra Binding (binding) of in striatum associated with dopamine, substantia nigra and morphine
3) Confidence 0.08 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2456939 Disease Relevance 0 Pain Relevance 0.86

General Comments

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