INT244093

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.38
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C2) extracellular region (C2) Golgi apparatus (Arhgap4)
nucleus (Arhgap4) cytoplasm (Arhgap4)
C2 (Mus musculus)
Arhgap4 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 16 88.28 High High
potassium channel 2 75.84 Quite High
Antinociceptive 30 56.96 Quite High
Potency 2 54.48 Quite High
Eae 6 49.76 Quite Low
chemokine 9 46.48 Quite Low
Inflammation 8 44.84 Quite Low
Analgesic 6 43.60 Quite Low
Opioid 4 43.16 Quite Low
bradykinin 2 41.84 Quite Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 59 89.28 High High
Targeted Disruption 28 63.84 Quite High
Inflammatory Pain 1 49.76 Quite Low
Stress 3 49.44 Quite Low
INFLAMMATION 10 44.84 Quite Low
Pain 7 40.64 Quite Low
Nociception 11 30.28 Quite Low
Infection 7 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results showed that compound C1 was more potent than C2 when given by p.o. administration.
C2 Binding (potent) of C1
1) Confidence 0.23 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2817697 Disease Relevance 0 Pain Relevance 0.06
In seven mice, the injection site was correctly targeted to the C2 barrel column, and in the other three mice nearby barrels (C1, D2, and D1/?)
C2 Binding (targeted) of C1
2) Confidence 0.05 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0.06 Pain Relevance 0.07
This multi-point interaction is formed by binding of the second extracellular loop (ECL-2) to elements of the gp120 V3 region and the tyrosine-sulfated N-terminus (Tyr-Nt) of CCR5 binding the more conserved bridging sheet that forms between the C1, C2, and C4 domains upon CD4 binding (Cormier and Dragic 2002; Huang et al 2007).


C2 Binding (binding) of C1
3) Confidence 0.00 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.31 Pain Relevance 0.07

General Comments

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