INT24410

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Context Info
Confidence 0.28
First Reported 1985
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.98
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinc1)
Anatomy Link Frequency
plasma 2
Serpinc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 7 98.88 Very High Very High Very High
epidural 1 93.36 High High
Pain 8 91.84 High High
anesthesia 1 83.44 Quite High
imagery 1 79.68 Quite High
Angina 1 78.16 Quite High
Morphine 1 67.40 Quite High
visual analogue scale 1 62.08 Quite High
Paracetamol 6 55.68 Quite High
Codeine 11 54.72 Quite High
Disease Link Frequency Relevance Heat
Fever 1 98.60 Very High Very High Very High
Disorder Of Lipid Metabolism 17 96.88 Very High Very High Very High
Pain 8 91.84 High High
Myocardial Infarction 3 90.64 High High
Acute Necrotizing Pancreatitis 4 86.04 High High
Pancreatitis 19 83.80 Quite High
Gallstones 7 81.68 Quite High
Vertigo 1 78.88 Quite High
Angina 1 78.16 Quite High
Sprains And Strains 1 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with DES resulted in significant increases in cumulative synthesis of factors II (65%) and VII (76%) and significant reduction in cumulative synthesis of both antithrombin III (20%; P = .03) and plasminogen (27%; P less than .01) compared to control perfusions, but synthesis of fibrinogen, fibronectin, and albumin was not significantly affected by addition of the hormone.
Negative_regulation (reduction) of Gene_expression (synthesis) of antithrombin III
1) Confidence 0.28 Published 1985 Journal Blood Section Abstract Doc Link 4016277 Disease Relevance 0 Pain Relevance 0.08
Nevertheless, the use of contraceptives has been implicated in triggering it by diminishing the synthesis of antithrombin III.
Negative_regulation (diminishing) of Gene_expression (synthesis) of antithrombin III
2) Confidence 0.24 Published 1988 Journal Pol Tyg Lek Section Abstract Doc Link 2457208 Disease Relevance 0.46 Pain Relevance 0.19
Both lasofoxifene and raloxifene reduced levels of fibrinogen and antithrombin III compared with placebo, with the reduction greater with lasofoxifene than with raloxifene.
Negative_regulation (reduced) of Gene_expression (levels) of antithrombin III
3) Confidence 0.09 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2773750 Disease Relevance 0.56 Pain Relevance 0.03
The patient was febrile and had an increased leukocyte blood count and plasma CRP as well as decreased levels of antithrombin and elevated levels of fibrinogen and fibrin d-dimer, indicating activation of the coagulation system.
Negative_regulation (decreased) of Gene_expression (levels) of antithrombin in plasma associated with fever
4) Confidence 0.01 Published 2004 Journal BMC Womens Health Section Body Doc Link PMC406515 Disease Relevance 0.96 Pain Relevance 0.61

General Comments

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