INT244123

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.42
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Defa1) extracellular region (Defa1)
Anatomy Link Frequency
T cells 2
epithelium 1
Paneth cell 1
keratinocytes 1
Defa1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 77 99.72 Very High Very High Very High
Crohn's disease 43 96.36 Very High Very High Very High
psoriasis 152 95.32 Very High Very High Very High
Inflammation 104 91.72 High High
Inflammatory response 7 86.32 High High
chemokine 9 74.16 Quite High
antagonist 1 72.20 Quite High
Inflammatory mediators 3 69.04 Quite High
potassium channel 2 58.56 Quite High
rheumatoid arthritis 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 209 99.34 Very High Very High Very High
Eczema 59 96.20 Very High Very High Very High
Disease 171 96.04 Very High Very High Very High
INFLAMMATION 100 91.72 High High
Targeted Disruption 12 89.52 High High
Skin Diseases 15 87.84 High High
Inflammatory Bowel Disease 40 80.00 Quite High
Viral Infection 4 75.96 Quite High
Colitis 4 69.76 Quite High
Enteritis 2 67.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Beta-defensins are secreted peptides of low molecular weight ranging from 3 to 5 kDa.
Localization (secreted) of defensin
1) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.83 Pain Relevance 0.28
From these studies we concluded that psoriatic keratinocytes are programmed to secrete large amounts of host defense proteins such as beta-defensins, in response to Th1 or Th17 cytokines.
Localization (secrete) of defensin in keratinocytes associated with psoriasis and cytokine
2) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.87 Pain Relevance 0.32
Defensins are secreted proteins that will easily pass basal membranes, and we expected that epithelium-expressed defensins would reach the circulation and could be measured in serum by ELISA.
Localization (secreted) of Defensin in epithelium
3) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.24 Pain Relevance 0
As the Paneth cell's foremost activity is the secretion of huge amounts of defensins, an attractive interrelation can be proposed for the decreased defensin functionality in Crohn's disease and the mutation in ATG16L1.
Localization (secretion) of defensin in Paneth cell associated with crohn's disease and disease
4) Confidence 0.78 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.83 Pain Relevance 0.25
In a broader concept, Peyrin-Biroulet and Chaimallard position defensins at the interface between innate and adaptive immunity, proposing that NOD2-mediated microbial recognition leads to secretion of defensins, which in turn attract immature dendritic cells, help in their maturation and promote the subsequent activation of T cells [22].
Localization (secretion) of defensin in T cells
5) Confidence 0.78 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.14 Pain Relevance 0.08
-defensin-2 secretion to activation by LPS also indicated the unresponsive nature of HCE-T cells. [24].
Localization (secretion) of defensin in T cells
6) Confidence 0.68 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.52 Pain Relevance 0.30

General Comments

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