INT244153

Context Info Confidence 0.46 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 1.36 Pain Relevance 0.63

cytosol (NOD1) signal transduction (NOD1) plasma membrane (NOD1) intracellular (NOD1) cytoplasm (NOD1)

NOD1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 24 90.32 cytokine 42 82.88 Inflammatory mediators 3 80.72 antagonist 3 73.52 agonist 9 5.00 Inflammatory response 9 5.00 Pain 3 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 36 90.32 Infection 15 87.12 Injury 9 86.60 Viral Infection 3 66.32 Burns 3 64.16 Apoptosis 24 24.24 Hyperplasia 3 5.00 Uveitis 3 5.00 Toxicity 3 5.00 Death 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

B phosphorylation upon PGN-ECndss treatment as well as IL-6 inducibility after UV exposure suggest a functional Nod1/Nod2-initiated NF?

Positive_regulation (functional) of Gene_expression (/) of Nod1

1) Confidence 0.46 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.68 Pain Relevance 0.26

Surprisingly, after 24 h, although Nod1 and Nod2 expression increased compared to the 6 h samples, all the studied Nod expression remained low compared to the non-exposed samples (Figure 6B).

Positive_regulation (increased) of Gene_expression (expression) of Nod1

2) Confidence 0.46 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.10

B phosphorylation upon PGN-ECndss treatment as well as IL-6 inducibility after UV exposure suggest a functional Nod1/Nod2-initiated NF?

Positive_regulation (suggest) of Gene_expression (/) of Nod1

3) Confidence 0.46 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.68 Pain Relevance 0.27

General Comments

This test has worked.