INT244169

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.92
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (RNGTT) nucleoplasm (RNGTT) nucleus (RNGTT)
nucleotidyltransferase activity (RNGTT)
Anatomy Link Frequency
T cells 6
astrocytes 1
RNGTT (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 124 100.00 Very High Very High Very High
Inflammation 111 100.00 Very High Very High Very High
Inflammatory mediators 7 91.36 High High
Inflammatory marker 1 77.36 Quite High
Inflammatory response 19 73.20 Quite High
agonist 25 72.44 Quite High
antagonist 7 71.76 Quite High
dexamethasone 43 69.00 Quite High
cINOD 1 46.20 Quite Low
Pain 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 139 100.00 Very High Very High Very High
Adhesions 4 92.72 High High
Glaucoma 2 79.76 Quite High
Viral Infection 6 75.52 Quite High
Ocular Hypertension 7 66.80 Quite High
Hyperglycemia 1 61.08 Quite High
Apoptosis 74 60.48 Quite High
Skin Atrophy 1 58.20 Quite High
Death 18 51.68 Quite High
Hypersensitivity 4 48.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytokine secretion of HCE-T cells after UV-B irradiation
Localization (secretion) of HCE in T cells associated with cytokine
1) Confidence 0.23 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.17
Based on our results showing a cellular response mediated by NLR sensor molecules, we sought to detect cytokine secretion of HCE-T cells after UV-B exposure.
Localization (secretion) of HCE in T cells associated with cytokine
2) Confidence 0.23 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.05 Pain Relevance 0.23
The concentration of cytokines secreted by HCE-T cells was measured according to the manufacturerÂ’s instruction for IL-1?
Localization (secreted) of HCE in T cells associated with cytokine
3) Confidence 0.22 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.18
It was constitutively secreted by HCE-T cells, and its level increased by only twofold after 24 h of UV-B irradiation.
Localization (secreted) of HCE in T cells
4) Confidence 0.22 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.08 Pain Relevance 0.26
Using western blotting technique, we aimed to detect the presence of Nalp1 and Nalp3 proteins in the HCE-T cells.
Localization (presence) of HCE in T cells
5) Confidence 0.22 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
-defensin-2 secretion to activation by LPS also indicated the unresponsive nature of HCE-T cells. [24].
Localization (secretion) of HCE in T cells
6) Confidence 0.21 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.52 Pain Relevance 0.30
The concentration of cytokines released by HCE cells was measured according to the manufacturerÂ’s instructions for IL-6 (eBioscience, San Diego, CA) and IL-8 (Raybiotech, Norcross, GA) and was adjusted by the number of remaining cells.


Localization (released) of HCE associated with cytokine
7) Confidence 0.17 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.05 Pain Relevance 0.14
Therefore, the objective of these studies was to determine the anti-inflammatory properties of BOL-303242-X, on the release of important inflammatory cytokines in cultured primary human conjunctival fibroblasts (HConFs), human corneal epithelial cells (HCEpiCs), human optic nerve astrocytes (HONAs), and human retinal endothelial cells (HRECs).
Spec (determine) Localization (release) of HCEpiCs in astrocytes associated with inflammation and cytokine
8) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 1.22 Pain Relevance 0.53

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