INT244171

Context Info Confidence 0.47 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0 Pain Relevance 0.28

cytosol (NOD1) signal transduction (NOD1) plasma membrane (NOD1) intracellular (NOD1) cytoplasm (NOD1)

Anatomy Link Frequency head 1 T cells 1 NOD1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 28 97.28 agonist 6 96.64 Inflammation 16 33.68 Inflammatory response 6 5.00 anesthesia 2 5.00 Pain 2 5.00 Inflammatory mediators 2 5.00 antagonist 2 5.00 Buprenorphine 1 5.00 analgesia 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 16 34.60 INFLAMMATION 24 33.68 Infection 10 5.00 Injury 6 5.00 Disease 3 5.00 Hyperplasia 2 5.00 Uveitis 2 5.00 Toxicity 2 5.00 Death 2 5.00 Wrinkles 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results imply that unlike the case of Nalps, there is a general early and long-term downregulation of the Nod sensors after UV-B irradiation.

Negative_regulation (downregulation) of Nod

1) Confidence 0.47 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.16

While UV-B irradiation exerted a downregulation of both Nalp and Nod mRNAs as well as those of inflammasome components in HCE-T cells, longer incubation of the cells after exposure resulted in recovery or upregulation only of the Nalp sensors.

Negative_regulation (downregulation) of Nod in T cells

2) Confidence 0.34 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.12

Modeling the interaural tVOR and the effect of Nod/Uv lesions: impaired integration of head acceleration

Negative_regulation (effect) of Nod/Uv in head

3) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981566 Disease Relevance 0 Pain Relevance 0

General Comments

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