INT2442

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Context Info
Confidence 0.80
First Reported 1977
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 38
Total Number 40
Disease Relevance 24.74
Pain Relevance 6.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Mb)
Anatomy Link Frequency
blood 5
plasma 4
muscle 3
myocardium 1
chest 1
Mb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 40 99.54 Very High Very High Very High
Pain 25 99.16 Very High Very High Very High
halothane 9 97.48 Very High Very High Very High
anesthesia 14 97.08 Very High Very High Very High
chest pain 4 91.56 High High
Percutaneous transluminal coronary angioplasty 8 86.48 High High
alcohol 8 83.08 Quite High
Inflammation 28 81.32 Quite High
imagery 15 79.12 Quite High
Central nervous system 6 70.60 Quite High
Disease Link Frequency Relevance Heat
Injury 36 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 11 100.00 Very High Very High Very High
Cv Unclassified Under Development 13 99.96 Very High Very High Very High
Urological Neuroanatomy 9 99.86 Very High Very High Very High
Muscle Disease 6 99.86 Very High Very High Very High
Myocardial Infarction 42 99.84 Very High Very High Very High
Disorders Of Creatine Metabolism 16 99.80 Very High Very High Very High
Necrosis 14 99.68 Very High Very High Very High
Rhabdomyolysis 46 99.62 Very High Very High Very High
Angina 13 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that short-term myocardial ischaemia without signs of established myocardial infarction may provoke myocardial myoglobin release.
Localization (release) of myoglobin associated with coronary artery disease and myocardial infarction
1) Confidence 0.80 Published 1984 Journal Clin Physiol Section Abstract Doc Link 6540152 Disease Relevance 0.64 Pain Relevance 0.36
Myoglobin release in patients with angina pectoris following short-term ischaemia by pacing to angina.
Localization (release) of Myoglobin associated with angina and cv unclassified under development
2) Confidence 0.80 Published 1984 Journal Clin Physiol Section Title Doc Link 6540152 Disease Relevance 0.57 Pain Relevance 0.47
Myoglobin excretion was found in 88% of the subjects who developed soreness.
Localization (excretion) of Myoglobin
3) Confidence 0.79 Published 1977 Journal Med Sci Sports Section Abstract Doc Link 870780 Disease Relevance 0.59 Pain Relevance 0
When the 60-min myoglobin ratio was >4.0, the probability of a patent IRA was 90%, suggesting that emergency coronary angiography to determine their IRA status may be unnecessary when this pattern of release of myoglobin is observed.
Localization (release) of myoglobin in IRA associated with emergencies
4) Confidence 0.79 Published 2005 Journal J. Thromb. Thrombolysis Section Abstract Doc Link 15976963 Disease Relevance 0.10 Pain Relevance 0.09
Rhabdomyolysis (literally "striped muscle dissolution") is a biological and clinical condition that takes to plasmatic release of myoglobin, muscle enzymes and electrolytes, relates to the lysis of stripped muscle fibers.
Localization (release) of myoglobin in muscle associated with rhabdomyolysis
5) Confidence 0.79 Published 1999 Journal Minerva Anestesiol Section Abstract Doc Link 10389401 Disease Relevance 0.72 Pain Relevance 0
However, when the damage is profound, there is a release of muscle proteins into the blood; one of these proteins, myoglobin, in high concentrations and under certain conditions (such as dehydration and heat stress) can precipitate in the kidneys, thereby resulting in acute renal failure.
Localization (release) of myoglobin in blood associated with acute renal failure, heat stress disorders and volume depletion and dehydration
6) Confidence 0.74 Published 2007 Journal Sports Med Section Abstract Doc Link 17465608 Disease Relevance 0.80 Pain Relevance 0.07
[Diagnostic value of serum myoglobin].
Localization (value) of serum myoglobin
7) Confidence 0.64 Published 1980 Journal Minerva Med. Section Title Doc Link 7432669 Disease Relevance 0.50 Pain Relevance 0.32
Myoglobin is but one substance that is liberated into the bloodstream.
Localization (liberated) of Myoglobin
8) Confidence 0.63 Published 1988 Journal Sports Med Section Abstract Doc Link 3062736 Disease Relevance 0.89 Pain Relevance 0.10
Brown discoloration of the urine and a falsely positive test for "blood" due to the presence of myoglobin in urine in the absence of red blood cells are also typical.
Localization (presence) of myoglobin in blood
9) Confidence 0.57 Published 1979 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 446285 Disease Relevance 0.57 Pain Relevance 0.13
Data on plasma hydroxybutyrate dehydrogenase activity (I) and myoglobin concentration were used to evaluate painful sickle cell crises.
Localization (concentration) of myoglobin in plasma associated with sickle cell anemia and pain
10) Confidence 0.56 Published 1981 Journal Clin. Chem. Section Abstract Doc Link 7460284 Disease Relevance 0.33 Pain Relevance 0.10
The remarkable formation of a stable, globular lipoprotein from constituent S-MB and SDS is attributed to the N-terminal residues (1–7) in S-MB (Fig. 2), as analogous dimers are not observed in SDS-PAGE of MB (Fig. 8).
Localization (attributed) of MB
11) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2805716 Disease Relevance 0 Pain Relevance 0
Space-filling models (not shown) confirm that the “10 nsec” dimer S-MB folds as a globular lipoprotein, consisting of a partial ‘micelle’ of ?
Localization (nsec) of dimer S-MB
12) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2805716 Disease Relevance 0.06 Pain Relevance 0
In the first 4 hours after onset of chest pain, the determination of myoglobin can have an advantage, since it is released into the blood stream at an earlier stage, but thereafter myoglobin can lead to false negative diagnosis.
Localization (released) of myoglobin in blood associated with angina
13) Confidence 0.45 Published 1994 Journal Eur J Clin Chem Clin Biochem Section Abstract Doc Link 7888482 Disease Relevance 0.27 Pain Relevance 0.10
In the first 4 hours after onset of chest pain, the determination of myoglobin can have an advantage, since it is released into the blood stream at an earlier stage, but thereafter myoglobin can lead to false negative diagnosis.
Localization (released) of myoglobin in blood associated with angina
14) Confidence 0.45 Published 1994 Journal Eur J Clin Chem Clin Biochem Section Abstract Doc Link 7888482 Disease Relevance 0.27 Pain Relevance 0.10
Rhabdomyolysis represents a life-threatening condition, which results in release of cellular contents (myoglobin, enzymes, and electrolytes) into the plasma.
Localization (release) of myoglobin in plasma associated with rhabdomyolysis
15) Confidence 0.44 Published 2003 Journal Pediatr. Nephrol. Section Abstract Doc Link 12736809 Disease Relevance 0.75 Pain Relevance 0.08
Effect of thiamylal and diazepam on release of myoglobin and creatine phosphokinase by succinylcholine chloride during halothane anesthesia.
Localization (release) of myoglobin associated with anesthesia, disorders of creatine metabolism and halothane
16) Confidence 0.44 Published 1985 Journal Bull. Tokyo Med. Dent. Univ. Section Title Doc Link 3865740 Disease Relevance 0.27 Pain Relevance 0.41
Acute exertional rhabdomyolysis is caused by a skeletal muscle injury that results in the release of myoglobin and other cellular contents into the circulatory system.
Localization (release) of myoglobin in skeletal muscle associated with injury and rhabdomyolysis
17) Confidence 0.44 Published 1995 Journal Am Fam Physician Section Abstract Doc Link 7625324 Disease Relevance 1.13 Pain Relevance 0.05
The effects of thiamylal and diazepam on the release of myoglobin and creatine phosphokinase following the administration of succinylcholine chloride during halothane anesthesia were studied.
Localization (release) of myoglobin associated with anesthesia, disorders of creatine metabolism and halothane
18) Confidence 0.44 Published 1985 Journal Bull. Tokyo Med. Dent. Univ. Section Abstract Doc Link 3865740 Disease Relevance 0.24 Pain Relevance 0.39
Our results indicate that thiamylal has a considerable inhibitory effect on the release of myoglobin and creatine phosphokinase from the muscle following the administration of succinylcholine chloride.
Localization (release) of myoglobin in muscle associated with disorders of creatine metabolism
19) Confidence 0.44 Published 1985 Journal Bull. Tokyo Med. Dent. Univ. Section Abstract Doc Link 3865740 Disease Relevance 0.33 Pain Relevance 0.33
On the basis of indirect evidences pigmenturia "per exclusionem" was a manifestation of urinary myoglobin excretion.
Localization (excretion) of myoglobin
20) Confidence 0.39 Published 1992 Journal Orv Hetil Section Abstract Doc Link 1495807 Disease Relevance 0.52 Pain Relevance 0.09

General Comments

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