INT24420

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Context Info
Confidence 0.69
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 3.32
Pain Relevance 4.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)
Anatomy Link Frequency
plasma 3
hypothalamus 2
spinal cord 1
pituitary 1
endocrine cell 1
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 6 100.00 Very High Very High Very High
analgesia 4 100.00 Very High Very High Very High
Spinal cord 3 99.12 Very High Very High Very High
Morphine 15 99.00 Very High Very High Very High
Cancer pain 2 98.88 Very High Very High Very High
vagus nerve 7 97.44 Very High Very High Very High
Endogenous opioid 7 97.24 Very High Very High Very High
medulla 31 96.52 Very High Very High Very High
Opioid 9 96.28 Very High Very High Very High
depression 5 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 44 100.00 Very High Very High Very High
Cancer Pain 2 98.88 Very High Very High Very High
Nociception 2 98.28 Very High Very High Very High
Depression 5 95.52 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 93.64 High High
Pain 10 93.24 High High
Recurrence 1 88.68 High High
Adrenal Insufficiency 2 87.16 High High
Targeted Disruption 15 85.52 High High
INFLAMMATION 5 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It can reduce the increased levels of corticotropin-releasing hormone mRNA expression in the hypothalamus and proopiomelanocortin mRNA expression in the pituitary, and reverse the decreased glucocorticoid receptor protein expression in the hypothalamus paraventricular nucleus to normal (40).


Transcription (expression) of proopiomelanocortin in nucleus
1) Confidence 0.69 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816380 Disease Relevance 0.82 Pain Relevance 0.09
CONCLUSIONS: D2R plays a critical role in the inhibitory regulation of endocrine cell proliferation and the transcription of POMC mRNA, and consequently in the regulation of alpha-MSH in plasma.
Transcription (transcription) of POMC mRNA in endocrine cell
2) Confidence 0.68 Published 1996 Journal Genes Cells Section Body Doc Link 9140068 Disease Relevance 0 Pain Relevance 0
Our study assessed the contribution of opioid receptors in stress-induced analgesia and adrenocorticotropic hormone (ACTH) and corticosterone release by a genetic approach.
Transcription (contribution) of ACTH associated with stress, opioid receptor and analgesia
3) Confidence 0.68 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16237385 Disease Relevance 0.79 Pain Relevance 0.76
We examined proopiomelanocortin (POMC) mRNA and beta-endorphin expression in the hypothalamus of mice after various nociceptive stimuli.
Spec (examined) Transcription (expression) of beta-endorphin in hypothalamus associated with nociception
4) Confidence 0.66 Published 2008 Journal Neuroscience Section Abstract Doc Link 18329177 Disease Relevance 0.17 Pain Relevance 0.19
POMC and the supraoptic nucleus of the hypothalamus
Transcription (supraoptic nucleus) of POMC in hypothalamus
5) Confidence 0.55 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.06 Pain Relevance 0.10
ACTH levels in response to the last morphine injection of the repeated dosage regimen were found to be lower compared to those in acutely morphine-treated mice.
Transcription (levels) of ACTH associated with morphine
6) Confidence 0.53 Published 2004 Journal Brain Res. Section Abstract Doc Link 15328032 Disease Relevance 0.15 Pain Relevance 0.80
Chronic treatment of rats with morphine by implantation of pellets over a period of 10 days resulted in a differential alteration of pro-opiomelanocortin (POMC) mRNA levels in individual pituitary lobes: Hybridisation studies using a 32P-labelled mouse POMC cDNA fragment of 150 bases as a probe revealed that chronic morphine treatment causes about 50% enhancement of POMC mRNA levels in the anterior lobe and about 40% decrease in the intermediate lobe of the pituitary.
Transcription (levels) of POMC in anterior lobe associated with morphine
7) Confidence 0.52 Published 1985 Journal Neuropeptides Section Abstract Doc Link 4000418 Disease Relevance 0 Pain Relevance 0.33
Furthermore, incubation of spinal cord explants with activin A or BMP-7 increased POMC and/or PENK mRNA levels.
Transcription (levels) of POMC in spinal cord associated with spinal cord
8) Confidence 0.52 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20107078 Disease Relevance 0.42 Pain Relevance 0.95
The pre-partum increase in foetal plasma ACTH is associated with a rise in pro-opiomelanocortin (POMC) mRNA in the foetal pars distalis, and with an altered pattern of POMC post-translational processing.
Transcription (rise) of pro-opiomelanocortin in plasma
9) Confidence 0.44 Published 1993 Journal Equine Vet J Suppl Section Abstract Doc Link 9079135 Disease Relevance 0 Pain Relevance 0.10
To evaluate the role of the pituitary in this gender difference, ACTH levels were determined after corticotropin-releasing factor (CRF) administration.
Transcription (levels) of ACTH in pituitary
10) Confidence 0.33 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9165495 Disease Relevance 0 Pain Relevance 0.50
Notably, exogenous CRH injection rapidly induces the ACTH secretion in these adrenalectomized mice, suggesting that CRH is essential to the ACTH secretion rather than the POMC gene transcription.
Transcription (transcription) of POMC gene
11) Confidence 0.18 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.63 Pain Relevance 0.15
Plasma Beta-endorphin levels before and after relief of cancer pain.
Transcription (levels) of Beta-endorphin in Plasma associated with cancer pain
12) Confidence 0.10 Published 2004 Journal Pain Physician Section Title Doc Link 16868614 Disease Relevance 0.19 Pain Relevance 0.47
They were then stained immunohistochemically to detect pro-opiomelanocortin (POMC)-derived peptides (ACTH, beta-endorphin and alpha-MSH).
Transcription (detect) of ACTH
13) Confidence 0.06 Published 1988 Journal Arch. Histol. Cytol. Section Abstract Doc Link 2457387 Disease Relevance 0 Pain Relevance 0.11
Outcome measures were the relative expression of clock gene mRNA (hperiod1, hperiod2, hclock) and the levels of serum cortisol, plasma ACTH, beta-endorphin (beta-EP), leptin, neuropeptide Y, interleukin-2 (IL-2), and tumor necrosis factor (TNF) in these subjects.
Transcription (expression) of ACTH in plasma
14) Confidence 0.01 Published 2009 Journal Biol. Psychiatry Section Body Doc Link 19135652 Disease Relevance 0.09 Pain Relevance 0

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