INT244226

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.81
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl11) extracellular region (Ccl11) cytoskeleton organization (Ccl11)
Anatomy Link Frequency
neutrophil 1
Ccl11 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 170 100.00 Very High Very High Very High
Inflammatory response 1 60.60 Quite High
tolerance 1 55.88 Quite High
antagonist 9 47.44 Quite Low
cytokine 53 46.24 Quite Low
rheumatoid arthritis 3 10.96 Low Low
IPN 3 5.80 Low Low
Inflammation 59 5.00 Very Low Very Low Very Low
Arthritis 21 5.00 Very Low Very Low Very Low
ischemia 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bronchitis 1 99.82 Very High Very High Very High
Emphysema 10 98.08 Very High Very High Very High
Pulmonary Disease 60 94.68 High High
Bronchial Hyperreactivity 1 94.36 High High
Eosinophilia 2 92.48 High High
Contagious Ecthyma 6 92.16 High High
Disease 66 82.08 Quite High
Helminth Infection 6 79.04 Quite High
Nicotine Addiction 6 74.88 Quite High
Infection 12 68.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CHBPs described here specifically inhibit the chemokines that recruit these cell types; Evasin-1 (in rodents) and Evasin-3 prevent neutrophil accumulation, and preliminary results indicate that Evasin-4 binds the eosinophil-recruiting chemokines CCL5 and CCL11.
CCL11 Binding (binds) of in neutrophil associated with chemokine
1) Confidence 0.25 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.08 Pain Relevance 0.44
Moreover, the expression of both eotaxin-1 and CCR3 is up regulated during exacerbations of chronic bronchitis[43] and eotaxin-1 levels are associated with bronchodilator response and the extent of emphysema on CT scans[44].
eotaxin-1 Binding (associated) of associated with emphysema and bronchitis
2) Confidence 0.24 Published 2009 Journal Respir Res Section Body Doc Link PMC2785783 Disease Relevance 1.41 Pain Relevance 0.14
The CCL5 and CCL11 binding protein was named Evasin-4.


CCL11 Binding (binding) of
3) Confidence 0.20 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.17 Pain Relevance 0.03
Deconvolution of the positive pools revealed a cDNA clone that was able to mediate cross-linking to both CCL5 and CCL11 (Fig. 2 a, lanes 4 and 5), but not CXCL10 when tested in HEK293 cells.
CCL11 Binding (linking) of
4) Confidence 0.20 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.15 Pain Relevance 0.04

General Comments

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