INT244286

Context Info Confidence 0.65 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.09 Pain Relevance 0.05

nucleus (Jak1) cytoplasm (Jak1)

Anatomy Link Frequency brain 1 Jak1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 11 92.56 Hippocampus 11 49.84 cytokine 6 31.68 anesthesia 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 11 92.56 Stress 3 35.84 Delirium 7 5.00 Sepsis 5 5.00 Decapitation 1 5.00 Neurodegenerative Disease 1 5.00 Apoptosis 1 5.00 Stroke 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, as IL-6 induces HO-1 mRNA through the JAK/stat pathway in the liver (Tron et al 2006), this mechanism may also work in the brain.

Gene_expression (pathway) of JAK in brain

1) Confidence 0.65 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526382 Disease Relevance 0.09 Pain Relevance 0.05

General Comments

This test has worked.