INT244320

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.51
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
lung 1
alveolar wall 1
neutrophils 1
Tlr4 (Mus musculus)
Aliq1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 23 100.00 Very High Very High Very High
ischemia 1 95.64 Very High Very High Very High
Inflammation 56 92.84 High High
cytokine 30 67.72 Quite High
chemokine 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
substance P 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 219 100.00 Very High Very High Very High
Hemorrhage 23 100.00 Very High Very High Very High
Sepsis 9 99.72 Very High Very High Very High
Pancreatitis 3 99.20 Very High Very High Very High
Burns 3 97.56 Very High Very High Very High
Hyperoxia 2 96.28 Very High Very High Very High
Cv Unclassified Under Development 1 95.64 Very High Very High Very High
Death 2 94.72 High High
INFLAMMATION 57 92.84 High High
Lung Injury 136 88.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immuno-histochemical and Western immunoblot studies in mice confirmed a) the presence of NEP in the alveolar wall, a critical target in ALI/ARDS, and b) a decrease in its expression in HCl- and LPS-induced ALI.


LPS Positive_regulation (induced) of ALI in alveolar wall associated with adult respiratory distress syndrome
1) Confidence 0.04 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3009633 Disease Relevance 0.97 Pain Relevance 0
To determine whether the decrease in lung NEP activity associated with ALI was due to a decrease in the expression of NEP protein in the lung, we measured the NEP protein content in lung homogenates using Western immunoblotting, and found that the expression of NEP protein in the lung in LPS-induced ALI was < 60% of the expression measured under control conditions (Figure 6).


LPS Positive_regulation (induced) of ALI in lung associated with adult respiratory distress syndrome
2) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.62 Pain Relevance 0
In conclusion, GMCSF plays an important role in not only LPS-induced but also hemorrhage-induced ALI by its priming effects on neutrophils.



LPS Positive_regulation (induced) of ALI in neutrophils associated with adult respiratory distress syndrome and cva
3) Confidence 0.02 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526424 Disease Relevance 0.93 Pain Relevance 0.42
This mechanism and the protective effects of PARP inhibitors have also been reported to play important roles in the cases of ALI induced by LPS [12], sepsis [14], acute pancreatitis [13], bleomycin [11], burn and smoke inhalation [25], hyperoxia [26], ischemia reperfusion [27], and hyperoxia [28].
LPS Positive_regulation (induced) of ALI associated with burns, ischemia, hyperoxia, pancreatitis, adult respiratory distress syndrome and sepsis
4) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 1.98 Pain Relevance 0.22

General Comments

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