INT244328

Context Info Confidence 0.20 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.26 Pain Relevance 0.04

cytoplasm (ELF3, SH3GL3) endosome (SH3GL3) Golgi apparatus (ELF3) extracellular matrix organization (ELF3) embryo development (ELF3) lipid binding (SH3GL3)

Anatomy Link Frequency urine 3 endothelium 2 plasma 1 ELF3 (Homo sapiens) SH3GL3 (Homo sapiens)

Pain Link Frequency Relevance Heat fibrosis 6 87.44 Pain 15 36.40 Pain score 3 13.12 Paracetamol 4 11.08 Central nervous system 7 5.00 ischemia 3 5.00 corticosteroid 2 5.00 carbamazepine 2 5.00 Antihistamine 2 5.00 tolerance 2 5.00

Disease Link Frequency Relevance Heat Fabry Disease 90 98.40 Proteinuria 91 93.60 Fibrosis 6 87.44 Albuminuria 4 85.72 Disease 36 80.72 Renal Disease 43 50.00 Pain 18 36.40 Hypohidrosis 11 35.36 Diarrhoea 4 33.92 Neurologic Manifestations 4 15.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

ERT resulted in decreased plasma and urine GL-3 levels even after a short-term treatment, and reduced GL-3 accumulation in various organs and tissues (24).

ERT Negative_regulation (reduced) of Positive_regulation (accumulation) of GL-3 in urine

1) Confidence 0.20 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526436 Disease Relevance 0.35 Pain Relevance 0

ERT was shown to reduce GL-3 accumulation in dermal endothelium in children with Fabry disease (Wraith et al 2008).

ERT Negative_regulation (reduce) of Positive_regulation (accumulation) of GL-3 in endothelium associated with fabry disease

2) Confidence 0.11 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 0.57 Pain Relevance 0.04

ERT resulted in decreased plasma and urine GL-3 levels even after a short-term treatment, and reduced GL-3 accumulation in various organs and tissues (24).

ERT Negative_regulation (reduced) of in plasma Positive_regulation (accumulation) of GL-3 in urine

3) Confidence 0.07 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526436 Disease Relevance 0.35 Pain Relevance 0

General Comments

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