INT244343

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Context Info
Confidence 0.73
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 14.26
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (NTM) plasma membrane (NTM)
Anatomy Link Frequency
lung 15
thymocyte 2
NTM (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 2 100.00 Very High Very High Very High
anesthesia 15 64.12 Quite High
Inflammation 30 34.16 Quite Low
Thoracotomy 15 5.68 Low Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 615 100.00 Very High Very High Very High
Adhesions 2 100.00 Very High Very High Very High
Disease 152 99.72 Very High Very High Very High
Postoperative Complications 60 99.34 Very High Very High Very High
Hemoptysis 105 98.92 Very High Very High Very High
Mycobacterial Infection 60 98.88 Very High Very High Very High
Bronchiectasis 60 97.92 Very High Very High Very High
Infection 180 97.88 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 45 97.48 Very High Very High Very High
Immunodeficiency 15 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SNX19 (sorting nexin-19), THYN1 (thymocyte nuclear protein 1), OPCML (opioid-binding protein/cell adhesion molecule-like), VPS26B (vacuolar protein sorting 26, yeast, homolog of B), NCAPD3 (non-SMC condensing II complex subunit D3) and NTM (neurotrimin) might be candidate genes, and the encoded proteins are associated with intracellular trafficking, phosphoinositide binding, mitotic chromosome assembly and segregation, outgrowth of neurites, and apoptosis.

8p23.3 deletion

Localization (opioid) of neurotrimin in thymocyte associated with apoptosis, opioid and adhesions
1) Confidence 0.73 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2892449 Disease Relevance 0.89 Pain Relevance 0.10
This was possible because, in recent years at our institution, surgery has been actively considered in patients with localized NTM lung disease when medical treatment appeared ineffective, before the lesions had become inoperable.
Localization (localized) of NTM in lung associated with pulmonary disease
2) Confidence 0.70 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526522 Disease Relevance 0.46 Pain Relevance 0
One retrospective study recommended that patients with localized NTM lung disease be considered for pulmonary resection as early as possible (14).
Localization (localized) of NTM in lung associated with pulmonary disease
3) Confidence 0.70 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526522 Disease Relevance 0.40 Pain Relevance 0
SNX19 (sorting nexin-19), THYN1 (thymocyte nuclear protein 1), OPCML (opioid-binding protein/cell adhesion molecule-like), VPS26B (vacuolar protein sorting 26, yeast, homolog of B), NCAPD3 (non-SMC condensing II complex subunit D3) and NTM (neurotrimin) might be candidate genes, and the encoded proteins are associated with intracellular trafficking, phosphoinositide binding, mitotic chromosome assembly and segregation, outgrowth of neurites, and apoptosis.

8p23.3 deletion

Localization (opioid) of NTM in thymocyte associated with apoptosis, opioid and adhesions
4) Confidence 0.66 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2892449 Disease Relevance 0.89 Pain Relevance 0.10
All the patients underwent lung resection to treat NTM lung disease or the complications of NTM lung disease and not for diagnostic purposes.
Localization (disease) of NTM in lung associated with pulmonary disease
5) Confidence 0.65 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526522 Disease Relevance 0.71 Pain Relevance 0
Of the various species of NTM, Mycobacterium avium-intracellulare complex (MAC), M. kansasii, and M. abscessus are the most common causes of NTM lung disease (1, 2).
Localization (disease) of NTM in lung associated with pulmonary disease
6) Confidence 0.65 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526522 Disease Relevance 1.61 Pain Relevance 0
This was possible because, in recent years at our institution, surgery has been actively considered in patients with localized NTM lung disease when medical treatment appeared ineffective, before the lesions had become inoperable.
Localization (disease) of NTM in lung associated with pulmonary disease
7) Confidence 0.65 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526522 Disease Relevance 0.46 Pain Relevance 0
Three patients who developed massive hemoptysis did not receive preoperative antibiotic therapy for NTM lung disease.
Localization (disease) of NTM in lung associated with pulmonary disease and hemoptysis
8) Confidence 0.65 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526522 Disease Relevance 0.94 Pain Relevance 0
Therefore, this study retrospectively examined the outcomes in patients who underwent pulmonary resections for NTM lung disease in recent years while taking the recommended standardized combination antibiotic therapy.


Localization (disease) of NTM in lung associated with pulmonary disease
9) Confidence 0.65 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526522 Disease Relevance 0.93 Pain Relevance 0
In conclusion, despite its relatively high surgical complication rate, patients with NTM lung disease whose disease is localized to one lung and who can tolerate resectional surgery might be considered for surgery, if there has been a poor response to drug therapy or if the patients develop significant disease-related complications such as hemoptysis.



Localization (disease) of NTM in lung associated with pulmonary disease, hemoptysis and disease
10) Confidence 0.65 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526522 Disease Relevance 0.75 Pain Relevance 0
Despite the favorable treatment outcomes, postoperative complications were relatively high (35%) with NTM lung disease in our study.
Localization (disease) of NTM in lung associated with pulmonary disease and postoperative complications
11) Confidence 0.65 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526522 Disease Relevance 0.71 Pain Relevance 0
During the study period, pulmonary resections for NTM lung disease were performed in 23 patients (7 men and 16 women) ranging in age between 24 and 66 yr (median, 45; interquartile range [IQR], 37 to 57).
Localization (disease) of NTM in lung associated with pulmonary disease
12) Confidence 0.65 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526522 Disease Relevance 0.48 Pain Relevance 0.06
One retrospective study recommended that patients with localized NTM lung disease be considered for pulmonary resection as early as possible (14).
Localization (disease) of NTM in lung associated with pulmonary disease
13) Confidence 0.65 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526522 Disease Relevance 0.40 Pain Relevance 0
Regarding the treatment of NTM lung disease, the American Thoracic Society has recommended that the initial therapy for patients with MAC lung disease consist of a minimum three-drug regimen of clarithromycin (or azithromycin), rifampin (or rifabutin), and ethambutol (1, 2).
Localization (disease) of NTM in lung associated with pulmonary disease
14) Confidence 0.65 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526522 Disease Relevance 0.63 Pain Relevance 0
Therefore, these patients have long been considered candidates for surgical treatment when the disease is localized (6-9), and this has been regarded as essential for the treatment of NTM lung disease.
Localization (disease) of NTM in lung associated with pulmonary disease and disease
15) Confidence 0.65 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526522 Disease Relevance 1.64 Pain Relevance 0
All the patients underwent lung resection to treat NTM lung disease or the complications of NTM lung disease and not for diagnostic purposes.
Localization (disease) of NTM in lung associated with pulmonary disease
16) Confidence 0.65 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526522 Disease Relevance 0.71 Pain Relevance 0
Of the various species of NTM, Mycobacterium avium-intracellulare complex (MAC), M. kansasii, and M. abscessus are the most common causes of NTM lung disease (1, 2).
Localization (disease) of NTM in lung associated with pulmonary disease
17) Confidence 0.65 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526522 Disease Relevance 1.66 Pain Relevance 0

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