INT244374

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.81
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Cl (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 92 99.82 Very High Very High Very High
Dorsal horn 4 81.36 Quite High
Hyperalgesia 24 72.08 Quite High
Dorsal horn neuron 2 54.88 Quite High
Inflammation 36 52.52 Quite High
GABAergic 10 48.20 Quite Low
Neuropathic pain 2 35.56 Quite Low
gABA 30 30.44 Quite Low
nociceptor 24 5.00 Very Low Very Low Very Low
substance P 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 132 99.62 Very High Very High Very High
Nociception 24 83.52 Quite High
Hyperalgesia 24 72.08 Quite High
Ganglion Cysts 4 50.00 Quite Low
Neurological Disease 2 44.56 Quite Low
Neuropathic Pain 10 35.56 Quite Low
Epilepsy 2 32.24 Quite Low
Peripheral Arterial Disease 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that the inflammatory mediators cause posttranslational changes such as phosphorylation and recruitment of Cl- transporters.
Phosphorylation (phosphorylation) of Cl associated with inflammatory mediators
1) Confidence 0.08 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.45 Pain Relevance 0.29
The temporal correlation between the p-NKCC1 signal and the rise of [Cl-]i suggests that Cl- uptake by NKCC1 is enhanced within 1–2 hours after treatment with inflammatory mediators through phosphorylation of the Cl- transporter.
Phosphorylation (phosphorylation) of Cl associated with inflammatory mediators
2) Confidence 0.08 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.36 Pain Relevance 0.18

General Comments

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