INT244376

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.86
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 4
Cl (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 24 99.12 Very High Very High Very High
Inflammatory stimuli 4 98.74 Very High Very High Very High
Inflammatory mediators 92 77.04 Quite High
Inflammation 36 72.92 Quite High
Spinal cord 4 70.24 Quite High
Central nervous system 2 63.84 Quite High
gABA 30 63.00 Quite High
algogenic 4 61.96 Quite High
GABAergic 10 60.36 Quite High
nociceptor 24 44.56 Quite Low
Disease Link Frequency Relevance Heat
Hyperalgesia 24 99.12 Very High Very High Very High
INFLAMMATION 132 98.58 Very High Very High Very High
Targeted Disruption 2 75.20 Quite High
Nociception 24 70.92 Quite High
Ganglion Cysts 4 50.00 Quite Low
Peripheral Arterial Disease 8 22.40 Low Low
Neuropathic Pain 10 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 4 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data demonstrate an impact of inflammatory stimuli on Cl- regulation in DRG neurons and support concepts for the role of Cl- accumulation in the generation of hyperalgesia.


Regulation (role) of Positive_regulation (accumulation) of Cl in neurons associated with hyperalgesia and inflammatory stimuli
1) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.61 Pain Relevance 0.48
In contrast, the efficiency of Cl- accumulation in DRG neurons appears to be regulated.
Spec (appears) Regulation (regulated) of Positive_regulation (accumulation) of Cl in neurons
2) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.26 Pain Relevance 0.15

General Comments

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