INT244383

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.82
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a2)
Anatomy Link Frequency
brush 1
Slc12a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 46 99.84 Very High Very High Very High
Inflammatory stimuli 2 88.88 High High
antagonist 3 56.88 Quite High
bradykinin 5 41.84 Quite Low
Inflammation 18 5.00 Very Low Very Low Very Low
gABA 15 5.00 Very Low Very Low Very Low
Hyperalgesia 12 5.00 Very Low Very Low Very Low
nociceptor 12 5.00 Very Low Very Low Very Low
substance P 10 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 66 99.64 Very High Very High Very High
Hypertrophy 11 86.24 High High
Chronic Renal Failure 124 85.04 High High
Ganglion Cysts 2 50.00 Quite Low
Natriuresis 2 12.96 Low Low
Hyperalgesia 12 5.00 Very Low Very Low Very Low
Nociception 12 5.00 Very Low Very Low Very Low
Neuropathic Pain 5 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 4 5.00 Very Low Very Low Very Low
Uremia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We tested for possible effects of the inflammatory mediators on the transcription of NKCC1 and KCC2 by semi-quantitative PCR analysis of the respective mRNAs.
Transcription (transcription) of NKCC1 associated with inflammatory mediators
1) Confidence 0.67 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.48 Pain Relevance 0.24
In contrast immunoperoxidase microscopy and confocal laser scanning microscopy demonstrated that NHE3 immunolabeling in the brush border of the proximal tubules was markedly enhanced in AngII-treated rats, suggesting that high plasma AngII levels may contribute to an enhanced renal Na+ and HCO3- reabsorption in kidney tubules by increasing the abundance of NHE3 and BSC-1 in mTAL cells as well as increasing NHE3 expression in the proximal tubule brush border.
Transcription (abundance) of BSC-1 in brush
2) Confidence 0.14 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.35 Pain Relevance 0.05

General Comments

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