INT244383

Context Info Confidence 0.67 First Reported 2005 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.82 Pain Relevance 0.29

plasma membrane (Slc12a2)

Anatomy Link Frequency brush 1 Slc12a2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammatory mediators 46 99.84 Inflammatory stimuli 2 88.88 antagonist 3 56.88 bradykinin 5 41.84 Inflammation 18 5.00 gABA 15 5.00 Hyperalgesia 12 5.00 nociceptor 12 5.00 substance P 10 5.00 Neuropeptide 6 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 66 99.64 Hypertrophy 11 86.24 Chronic Renal Failure 124 85.04 Ganglion Cysts 2 50.00 Natriuresis 2 12.96 Hyperalgesia 12 5.00 Nociception 12 5.00 Neuropathic Pain 5 5.00 Peripheral Arterial Disease 4 5.00 Uremia 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We tested for possible effects of the inflammatory mediators on the transcription of NKCC1 and KCC2 by semi-quantitative PCR analysis of the respective mRNAs.

Transcription (transcription) of NKCC1 associated with inflammatory mediators

1) Confidence 0.67 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.48 Pain Relevance 0.24

In contrast immunoperoxidase microscopy and confocal laser scanning microscopy demonstrated that NHE3 immunolabeling in the brush border of the proximal tubules was markedly enhanced in AngII-treated rats, suggesting that high plasma AngII levels may contribute to an enhanced renal Na+ and HCO3- reabsorption in kidney tubules by increasing the abundance of NHE3 and BSC-1 in mTAL cells as well as increasing NHE3 expression in the proximal tubule brush border.

Transcription (abundance) of BSC-1 in brush

2) Confidence 0.14 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.35 Pain Relevance 0.05

General Comments

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