INT244388

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.27
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gabrd)
Anatomy Link Frequency
neuronal 2
neurons 2
brain 2
boutons 2
Gabrd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 211 100.00 Very High Very High Very High
GABAergic 100 100.00 Very High Very High Very High
algogenic 2 98.32 Very High Very High Very High
Cannabinoid receptor 1 97.52 Very High Very High Very High
Sciatic nerve 18 96.32 Very High Very High Very High
nociceptor 12 96.12 Very High Very High Very High
unmyelinated 5 95.68 Very High Very High Very High
Morphine 1 92.48 High High
Pyramidal cell 26 92.20 High High
antagonist 65 91.96 High High
Disease Link Frequency Relevance Heat
Convulsion 78 100.00 Very High Very High Very High
Stress 4 99.98 Very High Very High Very High
Nervous System Injury 123 99.72 Very High Very High Very High
Death 8 98.96 Very High Very High Very High
Status Epilepticus 63 93.40 High High
Epilepsy 61 85.92 High High
Nociception 12 85.04 High High
Injury 22 79.04 Quite High
Neuropathic Pain 41 77.44 Quite High
Cognitive Disorder 2 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that there is no significant loss of GABAergic boutons from the denervated area after SNI (which is consistent with the finding that neuronal death does not occur in this model) and that there is no depletion of GABA or GABAA receptors at GABAergic synapses within this region.
Neg (no) Regulation (depletion) of Gene_expression (receptors) of GABAA in boutons associated with gaba, nervous system injury, gabaergic and death
1) Confidence 0.38 Published 2008 Journal Neuroscience Section Abstract Doc Link PMC2553186 Disease Relevance 0.70 Pain Relevance 0.63
2/3 antibody seen by Moore et al. (2002) suggests that the levels of extrasynaptic GABAA receptor are also not altered after SNI.
Neg (not) Regulation (altered) of Gene_expression (levels) of extrasynaptic GABAA receptor associated with nervous system injury
2) Confidence 0.23 Published 2008 Journal Neuroscience Section Body Doc Link PMC2553186 Disease Relevance 0.70 Pain Relevance 0.37
To further complicate these studies, handling, caloric restriction, and even swim stress regulate GABAA receptor subunit expression, at times with a lasting effect, suggesting that epigenetic influences may be as important in shaping the GABAA receptor related differentiation and communication patterns [122,170, 202, 238].


Regulation (regulate) of Gene_expression (expression) of GABAA receptor associated with stress
3) Confidence 0.15 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.16 Pain Relevance 0.14
In contrast to resting activity, which in many individual neurons and in the total PTN population did not change after blockade of GABAA inhibition, activity during postural corrections was affected by GABAA receptor antagonism in 93% (all but two) of the PTNs.
Regulation (affected) of Gene_expression (antagonism) of GABAA receptor in neurons
4) Confidence 0.15 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2777253 Disease Relevance 0 Pain Relevance 0.11
Other authors have also reported considerable differences in the effects of a GABAA receptor blockade between individual neurons and between neuronal networks (e.g.
Regulation (effects) of Gene_expression (blockade) of GABAA receptor in neuronal
5) Confidence 0.15 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2777253 Disease Relevance 0 Pain Relevance 0.16
There is extensive evidence that seizures trigger alterations in the GABAergic inhibition as well as in the GABAA receptor subunit expression in the adult [74], [75], [76] and immature (P9) rat brain [77].
Regulation (alterations) of Gene_expression (expression) of GABAA receptor subunit in brain associated with convulsion and gabaergic
6) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.59 Pain Relevance 0.21
Interestingly, the effects of prolonged seizures on GABAA receptor expression and function are different in younger rats (Fig. 5), an observation that may partially explain the different outcomes of SE in very young vs older subjects.
Regulation (effects) of Gene_expression (expression) of GABAA receptor associated with convulsion
7) Confidence 0.11 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.72 Pain Relevance 0.04
These authors found expression of the GABAA receptor subunits ?
Regulation (found) of Gene_expression (expression) of GABAA receptor
8) Confidence 0.06 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.40 Pain Relevance 1.42

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