INT244392

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.05
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a2)
Anatomy Link Frequency
spinal 1
neurons 1
Slc12a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 20 100.00 Very High Very High Very High
Hyperalgesia 38 99.40 Very High Very High Very High
Spinal cord 30 93.72 High High
Inflammatory mediators 92 93.36 High High
Dorsal horn neuron 2 92.40 High High
Dorsal horn 7 91.80 High High
Inflammation 37 88.80 High High
allodynia 11 83.84 Quite High
qutenza 5 83.12 Quite High
Pain 9 71.88 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 36 100.00 Very High Very High Very High
Hyperalgesia 66 99.40 Very High Very High Very High
INFLAMMATION 133 92.96 High High
Contusions 4 92.40 High High
Spinal Cord Injury 72 91.60 High High
Nociception 31 90.72 High High
Pain 9 71.88 Quite High
Injury 12 71.36 Quite High
Pruritus 3 65.84 Quite High
Targeted Disruption 3 53.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes of Cl- regulation that led to disinhibition of these spinal neurons and to referred mechanical hyperalgesia involved a rapid and transient increase of NKCC1 phosphorylation followed by increased recruitment of NKCC1 protein to the plasma membrane within 3 hours [33].
NKCC1 Binding (recruitment) of in spinal associated with hyperalgesia
1) Confidence 0.35 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.42 Pain Relevance 0.30
We stained cryosections with antibodies raised against NKCC1 and KCC2, and we compared the mean fluorescence intensity of the stained neurons in each test DRG (FItest) to that of the corresponding contralateral control DRG (FIctr).
NKCC1 Binding (raised) of in neurons
2) Confidence 0.35 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.35 Pain Relevance 0.18
NKCC1 and KCC2 in neuropathic pain
NKCC1 Binding (pain) of associated with neuropathic pain
3) Confidence 0.31 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.28 Pain Relevance 1.20

General Comments

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