INT24440

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Context Info
Confidence 0.59
First Reported 1988
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.52
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Spink1)
Anatomy Link Frequency
pancreas 1
Spink1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 12 99.92 Very High Very High Very High
Inflammation 1 74.68 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 19 99.92 Very High Very High Very High
Stomach Cancer 1 98.76 Very High Very High Very High
Malignant Neoplastic Disease 1 98.28 Very High Very High Very High
Appetite Loss 1 98.08 Very High Very High Very High
Disease 2 97.88 Very High Very High Very High
Colon Cancer 2 96.52 Very High Very High Very High
Gastrointestinal Neoplasms 1 75.00 Quite High
INFLAMMATION 1 74.68 Quite High
Hypercalcemia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adaptive response of the rat pancreas to dietary substrates: parallel regulation of trypsinogen and pancreatic secretory trypsin inhibitor.
Regulation (regulation) of pancreatic secretory trypsin inhibitor in pancreas
1) Confidence 0.59 Published 2000 Journal Pancreas Section Title Doc Link 10975713 Disease Relevance 0.27 Pain Relevance 0.14
CONCLUSION: Our data does not support the hypothesis that a dysbalance of PSTI/trypsinogen ratio is a causative factor for CP.


Regulation (dysbalance) of PSTI
2) Confidence 0.42 Published 2002 Journal Pancreatology Section Body Doc Link 12123090 Disease Relevance 0.08 Pain Relevance 0
The sensitivity of serum PSTI measurements in patients with these three malignant diseases was only about 30%.
Regulation (sensitivity) of PSTI associated with malignant neoplastic disease and disease
3) Confidence 0.15 Published 1988 Journal Int. J. Pancreatol. Section Abstract Doc Link 2459273 Disease Relevance 1.12 Pain Relevance 0.17
In particular, the kindred with the R896H mutation presenting with a similar pedigree to the family described above may indicate a role for CASR gene mutations in SPINK1-related CP.
Regulation (role) of SPINK1-related
4) Confidence 0.04 Published 2006 Journal Scand. J. Gastroenterol. Section Body Doc Link 16497624 Disease Relevance 0.05 Pain Relevance 0

General Comments

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