INT244418

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.63
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ctsa) nucleolus (Ctsa) nucleus (Ctsa)
molecular_function (Ctsa) cellular_component (Ctsa) biological_process (Ctsa)
Ctsa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Lasting pain 8 99.68 Very High Very High Very High
Spinal cord 38 85.04 High High
allodynia 8 82.36 Quite High
Inflammation 6 79.92 Quite High
Neuropathic pain 20 78.12 Quite High
Hyperalgesia 4 74.00 Quite High
Pain 20 70.24 Quite High
Peripheral nerve injury 2 63.48 Quite High
medulla 4 19.84 Low Low
Dorsal horn 6 6.32 Low Low
Disease Link Frequency Relevance Heat
Pain 28 99.24 Very High Very High Very High
Disease 6 85.84 High High
Motor Neuron Diseases 2 84.24 Quite High
Neuropathic Pain 34 82.36 Quite High
INFLAMMATION 6 79.92 Quite High
Hyperalgesia 4 74.00 Quite High
Nervous System Injury 2 63.48 Quite High
Gliosis 2 22.40 Low Low
Injury 8 5.00 Very Low Very Low Very Low
Gastritis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact there is recent evidence in favor of the idea that the cathepsin inhibitors are also regulated during persistent pain states [36].
Regulation (regulated) of Negative_regulation (inhibitors) of cathepsin associated with pain and lasting pain
1) Confidence 0.11 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.84 Pain Relevance 0.62
This apparent contradiction might be explained by either an increase of the active form of CATX, that is still below the detection level of the Western Blot, or a concomitant regulation of endogenous cathepsin inhibitors, the cystatins or thyropins [34,35].
Regulation (regulation) of Negative_regulation (inhibitors) of cathepsin
2) Confidence 0.11 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.79 Pain Relevance 0.58

General Comments

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