INT24442

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Context Info
Confidence 0.36
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.38
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (FBF1) cytoplasm (FBF1)
Anatomy Link Frequency
forearm 1
brachial artery 1
finger 1
FBF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 8 99.54 Very High Very High Very High
substance P 32 98.74 Very High Very High Very High
Migraine 152 97.72 Very High Very High Very High
adenocard 4 94.40 High High
agonist 4 88.20 High High
antagonist 8 85.16 High High
Triptan 2 77.20 Quite High
headache 20 76.84 Quite High
cINOD 2 76.08 Quite High
Paracetamol 2 74.44 Quite High
Disease Link Frequency Relevance Heat
Headache 150 97.72 Very High Very High Very High
Increased Venous Pressure Under Development 39 94.00 High High
Sprains And Strains 6 82.04 Quite High
Epilepsy 30 76.12 Quite High
INFLAMMATION 2 75.84 Quite High
Migraine Without Aura 16 67.76 Quite High
Migraine With Aura 6 65.72 Quite High
Depression 10 5.00 Very Low Very Low Very Low
Thrombosis 4 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the decreases in FBF induced by clonidine and angiotensin II were not significantly different before and during ketanserin infusion.
Negative_regulation (decreases) of FBF associated with clonidine
1) Confidence 0.36 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3364592 Disease Relevance 0.50 Pain Relevance 0.17
Total FBF was measured by venous occlusion, air plethysmography, and capillary blood flow (FCF) by the disappearance rate of a radioisotope from a fingertip injection. 5-HT in doses of 4 and 8 micrograms/min, given by constant infusion via a brachial artery catheter, significantly decreased FBF [32 +/- (SE) 10.4 to 12.8 +/- 6.6 for 4 micrograms/min and to 5.4 +/- 2.6 ml.min-1.100 ml-1 for 8 micrograms/min, P less than 0.05].
Negative_regulation (decreased) of FBF in brachial artery
2) Confidence 0.36 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3364592 Disease Relevance 0.40 Pain Relevance 0.10
Intra-arterial phenylephrine and clonidine produced dose-related decreases in FBF and increases in finger vascular resistance (FVR); clonidine was the more potent vasoconstrictor.
Negative_regulation (decreases) of FBF in finger associated with clonidine
3) Confidence 0.27 Published 1988 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2459515 Disease Relevance 0.23 Pain Relevance 0.47
All three alpha-adrenergic constrictor drugs caused marked reductions in FBF and calculated forearm vascular conductance (P < 0.05).
Negative_regulation (reductions) of FBF in forearm
4) Confidence 0.20 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12923119 Disease Relevance 0.48 Pain Relevance 0.42
L-NMMA decreased FBF in a dose-dependent fashion (Table 2, Figure 3).
Negative_regulation (decreased) of FBF
5) Confidence 0.03 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0.80 Pain Relevance 1.16
In both migraine patients and control subjects, SNP and substance P caused a dose-dependent increase, and L-NMMA a dose-dependent decrease in FBF (P < 0.001 for all responses).
Negative_regulation (decrease) of FBF associated with migraine and substance p
6) Confidence 0.03 Published 2010 Journal BMC Neurol Section Abstract Doc Link PMC3017034 Disease Relevance 0.98 Pain Relevance 0.85

General Comments

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