INT24444

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Context Info
Confidence 0.12
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 5.55
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (FBF1) cytoplasm (FBF1)
Anatomy Link Frequency
endothelial cell 2
arm 1
sympathetic 1
smooth muscle cell 1
FBF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 4 99.38 Very High Very High Very High
Migraine 608 99.32 Very High Very High Very High
substance P 128 98.04 Very High Very High Very High
Serotonin 8 90.28 High High
headache 80 83.40 Quite High
antagonist 10 74.68 Quite High
agonist 1 74.04 Quite High
Triptan 8 70.04 Quite High
cINOD 8 68.92 Quite High
Paracetamol 8 67.28 Quite High
Disease Link Frequency Relevance Heat
Migraine Without Aura 64 99.58 Very High Very High Very High
Increased Venous Pressure Under Development 68 98.60 Very High Very High Very High
Headache 600 98.32 Very High Very High Very High
Epilepsy 120 88.04 High High
Attention Deficit Hyperactivity Disorder 8 85.24 High High
Sprains And Strains 24 77.12 Quite High
INFLAMMATION 8 68.68 Quite High
Hypersensitivity 8 66.52 Quite High
Migraine With Aura 24 58.56 Quite High
Depression 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prazosin effectively blocked the vasoconstrictor effect of phenylephrine but not clonidine and yet caused no significant change in FBF and FVR during reflex sympathetic vasoconstriction.
Neg (no) Regulation (change) of FBF in sympathetic associated with increased venous pressure under development and clonidine
1) Confidence 0.12 Published 1988 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2459515 Disease Relevance 0.26 Pain Relevance 0.49
A recent study in patients with migraine without aura, showed an impaired FBF response to the NO donor SNP, leading the authors to the hypothesis that vascular smooth muscle cell function is impaired in migraine without aura [26].
Regulation (response) of FBF in smooth muscle cell associated with migraine
2) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 1.10 Pain Relevance 0.95
FBF responses were expressed as absolute FBF in ml.min-1.dL-1 forearm for SNP and Substance P and as percentage change from baseline in the FBF-ratio between infused and non-infused arm for L-NMMA, as discussed previously [20].
Regulation (responses) of FBF in arm associated with substance p
3) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0 Pain Relevance 0.08
Plethysmographic data were extracted from Chart data files and FBF responses were calculated for individual plethysmographic tracings using a template spreadsheet (Microsoft Excel 2000 v9.0, Microsoft Corporation, USA).
Regulation (responses) of FBF
4) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0 Pain Relevance 0.04
Compared to healthy controls, FBF response to acetylcholine was impaired, but as FBF response to SNP, i.e endothelial-independent vasodilation, was impaired while acetylcholine-induced release of NO was intact, the authors hypothesized that vascular smooth muscle cell, but not endothelial cell function is impaired in migraine without aura.
Regulation (response) of FBF in endothelial cell associated with migraine and increased venous pressure under development
5) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 1.14 Pain Relevance 0.71
FBF responses and t-PA release were comparable between migraine patients and control subjects.


Regulation (responses) of FBF associated with migraine
6) Confidence 0.02 Published 2010 Journal BMC Neurol Section Abstract Doc Link PMC3017034 Disease Relevance 0.91 Pain Relevance 0.79
The mean difference in FBF response to L-NMMA was 2% (95% CI, -10 to 13).
Regulation (response) of FBF
7) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0.96 Pain Relevance 1.19
Compared to healthy controls, FBF response to acetylcholine was impaired, but as FBF response to SNP, i.e endothelial-independent vasodilation, was impaired while acetylcholine-induced release of NO was intact, the authors hypothesized that vascular smooth muscle cell, but not endothelial cell function is impaired in migraine without aura.
Regulation (response) of FBF in endothelial cell associated with migraine and increased venous pressure under development
8) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 1.08 Pain Relevance 0.65
As a summary measure, the mean difference in FBF response between groups, expressed as change in FBF from baseline to the highest infused dose, was calculated together with the 95% confidence interval (CI).
Regulation (change) of FBF
9) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0.09 Pain Relevance 0.16

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