INT244449

Context Info Confidence 0.15 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.83 Pain Relevance 0.08

nucleoplasm (ATF4) mitochondrion (CS) small molecule metabolic process (CS) DNA binding (ATF4) carbohydrate metabolic process (CS) microtubule organizing center (ATF4)

CS (Homo sapiens) ATF4 (Homo sapiens)

Pain Link Frequency Relevance Heat addiction 2 76.36 Nicotine 18 5.00 Inflammation 10 5.00 COX-2 inhibitor 2 5.00 cINOD 2 5.00 Inflammatory response 2 5.00

Disease Link Frequency Relevance Heat Stress 134 93.92 Malignant Neoplastic Disease 40 50.00 Apoptosis 16 43.92 Lung Cancer 94 5.00 Cancer 80 5.00 Nicotine Addiction 60 5.00 Hypoxia 24 5.00 Carcinoma 24 5.00 Non-small-cell Lung Cancer 18 5.00 Small Cell Lung Cancer 16 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Effect of CS on ATF4 levels and expression of ATF4-dependent genes

CS Regulation (Effect) of Gene_expression (expression) of ATF4

1) Confidence 0.15 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.41 Pain Relevance 0.04

Effect of CS on ATF4 levels and expression of ATF4-dependent genes

CS Regulation (Effect) of Gene_expression (expression) of ATF4-dependent

2) Confidence 0.09 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.41 Pain Relevance 0.04

General Comments

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