INT24445

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Context Info
Confidence 0.35
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 2.73
Pain Relevance 3.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (FBF1) cytoplasm (FBF1)
Anatomy Link Frequency
arm 3
forearm 1
finger 1
FBF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 30 100.00 Very High Very High Very High
Clonidine 4 99.98 Very High Very High Very High
Migraine 456 98.64 Very High Very High Very High
substance P 96 98.48 Very High Very High Very High
Triptan 6 97.92 Very High Very High Very High
cINOD 6 96.80 Very High Very High Very High
Paracetamol 6 95.16 Very High Very High Very High
Analgesic 6 94.64 High High
antagonist 8 85.00 Quite High
agonist 1 84.36 Quite High
Disease Link Frequency Relevance Heat
Depression 30 100.00 Very High Very High Very High
Headache 450 98.64 Very High Very High Very High
INFLAMMATION 6 96.56 Very High Very High Very High
Increased Venous Pressure Under Development 52 88.80 High High
Migraine Without Aura 48 88.48 High High
Migraine With Aura 18 86.44 High High
Thrombosis 12 53.72 Quite High
Epilepsy 90 50.80 Quite High
Sprains And Strains 18 5.00 Very Low Very Low Very Low
Hypertension 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intra-arterial phenylephrine and clonidine produced dose-related decreases in FBF and increases in finger vascular resistance (FVR); clonidine was the more potent vasoconstrictor.
Gene_expression (produced) of FBF in finger associated with clonidine
1) Confidence 0.35 Published 1988 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2459515 Disease Relevance 0.23 Pain Relevance 0.47
FBF responses were expressed as absolute FBF in ml.min-1.dL-1 forearm for SNP and Substance P and as percentage change from baseline in the FBF-ratio between infused and non-infused arm for L-NMMA, as discussed previously [20].
Gene_expression (expressed) of FBF in arm associated with substance p
2) Confidence 0.05 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0 Pain Relevance 0.08
FBF responses were expressed as absolute FBF in ml.min-1.dL-1 forearm for SNP and Substance P and as percentage change from baseline in the FBF-ratio between infused and non-infused arm for L-NMMA, as discussed previously [20].
Gene_expression (expressed) of FBF in arm associated with substance p
3) Confidence 0.05 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0 Pain Relevance 0.08
CSD: cortical spreading depression; ET-1: endothelin-1; FBF: forearm blood flow; FMD: flow-mediated dilation; L-NMMA: NG-monomethyl-L-arginine; NO: nitric oxide; NOS: nitric oxide synthase; SBP: systolic blood pressure; SNP: sodium nitroprusside; t-PA: tissue plasminogen activator

Competing interests

Gene_expression (depression) of FBF in forearm associated with depression
4) Confidence 0.04 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0.74 Pain Relevance 0.45
The FBF response to L-NMMA was comparable between migraine patients and controls (P = 0.50).
Gene_expression (response) of FBF associated with migraine
5) Confidence 0.04 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0.90 Pain Relevance 1.20
Blood pressure, heart rate and FBF in the non-infused arm did not change during the infusions (data on file; Table 2).
Gene_expression (pressure) of FBF in arm
6) Confidence 0.04 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0.76 Pain Relevance 1.20
As a summary measure, the mean difference in FBF response between groups, expressed as change in FBF from baseline to the highest infused dose, was calculated together with the 95% confidence interval (CI).
Gene_expression (expressed) of FBF
7) Confidence 0.04 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0.10 Pain Relevance 0.16

General Comments

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