INT244452

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.07
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF2S2) mitochondrion (CS) small molecule metabolic process (CS)
RNA binding (EIF2S2) translation factor activity, nucleic acid binding (EIF2S2) translation (EIF2S2)
CS (Homo sapiens)
EIF2S2 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 5 99.92 Very High Very High Very High
Nicotine 45 40.52 Quite Low
Inflammatory response 5 22.44 Low Low
Inflammation 25 5.00 Very Low Very Low Very Low
COX-2 inhibitor 5 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 335 100.00 Very High Very High Very High
Cancer 200 95.56 Very High Very High Very High
Disease 35 94.88 High High
Nicotine Addiction 150 70.40 Quite High
Lung Cancer 235 70.32 Quite High
Malignant Neoplastic Disease 100 50.00 Quite Low
Apoptosis 40 30.00 Quite Low
INFLAMMATION 35 22.08 Low Low
Hypoxia 60 5.00 Very Low Very Low Very Low
Carcinoma 60 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Support for this hypothesis comes, in part, from the data presented in this study showing that CS causes ER stress and activates the UPR pathway via phosphorylation of eIF2?
CS Positive_regulation (activates) of Phosphorylation (phosphorylation) of eIF2 associated with stress
1) Confidence 0.21 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.68 Pain Relevance 0
when treated with CS (Panel A) or thapsigargin (Panel B), indicating that PERK is the major effector of CS-induced phosphorylation of eIF2?
CS Positive_regulation (induced) of Phosphorylation (phosphorylation) of eIF2
2) Confidence 0.12 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.37 Pain Relevance 0.04
The results shown in Figure 9 indicated that the vapor phase is as efficient as whole CS in inducing ER stress and the phosphorylation of eIF2?.
CS Positive_regulation (inducing) of Phosphorylation (phosphorylation) of eIF2 associated with stress
3) Confidence 0.12 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.30 Pain Relevance 0
Consequently, in order to show that CS treatment induces ER stress, it is important to demonstrate the dependence of CS-induced phosphorylation of eIF2?
CS Positive_regulation (induced) of Phosphorylation (phosphorylation) of eIF2 associated with stress and addiction
4) Confidence 0.12 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.36 Pain Relevance 0.05
CS treatment induces the phosphorylation of eIF2?
CS Positive_regulation (induces) of Phosphorylation (phosphorylation) of eIF2
5) Confidence 0.12 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.37 Pain Relevance 0

General Comments

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