INT244458

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.71
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CS) small molecule metabolic process (CS) mRNA processing (ERN1)
endoplasmic reticulum (ERN1) carbohydrate metabolic process (CS)
CS (Homo sapiens)
ERN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 18 30.56 Quite Low
Inflammation 10 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 60 85.60 High High
Adenocarcinoma 4 81.48 Quite High
Death 6 76.72 Quite High
Stress 134 75.28 Quite High
Apoptosis 16 74.60 Quite High
Malignant Neoplastic Disease 40 50.00 Quite Low
Lung Cancer 94 40.84 Quite Low
Cancer 80 13.28 Low Low
Hypoxia 24 5.00 Very Low Very Low Very Low
Carcinoma 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The conclusion of this paper was that CS did not activate the IRE1 sensor and therefore resulted in negligible XBP1 splicing.
CS Neg (not) Positive_regulation (activate) of IRE1
1) Confidence 0.17 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.71 Pain Relevance 0
We note that Hengstermann and Muller [31] also found a lack of XBP1 splicing but concluded from their data that activation of IRE1 (which induces XBP1 splicing) by CS is negligible.
CS Positive_regulation (activation) of IRE1
2) Confidence 0.12 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0 Pain Relevance 0

General Comments

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