INT244459

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.47
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK8) mitochondrion (MAPK8) endoplasmic reticulum (ERN1)
response to stress (MAPK8) cytoplasm (MAPK8) cytosol (MAPK8)
ERN1 (Homo sapiens)
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 9 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 67 100.00 Very High Very High Very High
Apoptosis 8 100.00 Very High Very High Very High
Repression 1 74.32 Quite High
Nicotine Addiction 30 56.00 Quite High
Malignant Neoplastic Disease 20 50.00 Quite Low
Cancer 40 39.08 Quite Low
Syndrome 2 38.60 Quite Low
Cardiovascular Disease 2 37.04 Quite Low
Diabetes Mellitus 2 36.08 Quite Low
Death 3 25.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to these pro-survival functions, IRE-1 can also directly regulate both pro- and anti-apoptotic circuits via activation of the stress kinase JNK-1 and mitogen-activated protein kinase ERK-1 [24-26].
IRE-1 Regulation (regulate) of Positive_regulation (activation) of kinase JNK-1 associated with stress and apoptosis
1) Confidence 0.03 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.47 Pain Relevance 0

General Comments

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