INT244470

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.69
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF6, XBP1) nucleus (ATF6, XBP1) protein folding (ATF6)
signal transduction (ATF6) nuclear envelope (ATF6) endoplasmic reticulum (ATF6)
Anatomy Link Frequency
cleavage 1
ATF6 (Homo sapiens)
XBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 9 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 30 95.76 Very High Very High Very High
Stress 67 92.40 High High
Death 3 86.52 High High
Cancer 40 78.16 Quite High
Malignant Neoplastic Disease 20 50.00 Quite Low
Adenocarcinoma 2 49.04 Quite Low
Disease 7 46.96 Quite Low
Apoptosis 8 42.16 Quite Low
Hypoxia 12 38.00 Quite Low
Lung Cancer 47 8.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, we showed that the third effector arm of the UPR signaling pathway, ATF6, is also activated by CS as evidenced by cleavage of the ATF6 protein and the appearance of downstream transcriptional targets of ATF6 such as XBP1 and BiP.
ATF6 Regulation (targets) of XBP1 in cleavage
1) Confidence 0.22 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.69 Pain Relevance 0

General Comments

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