INT244474

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (XBP1) mitochondrion (CS) small molecule metabolic process (CS)
nucleus (XBP1) DNA binding (XBP1) carbohydrate metabolic process (CS)
Anatomy Link Frequency
arms 1
A549 1
CS (Homo sapiens)
XBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 18 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 40 89.12 High High
Stress 134 50.00 Quite Low
Lung Cancer 94 5.00 Very Low Very Low Very Low
Cancer 80 5.00 Very Low Very Low Very Low
Nicotine Addiction 60 5.00 Very Low Very Low Very Low
Hypoxia 24 5.00 Very Low Very Low Very Low
Carcinoma 24 5.00 Very Low Very Low Very Low
Non-small-cell Lung Cancer 18 5.00 Very Low Very Low Very Low
Apoptosis 16 5.00 Very Low Very Low Very Low
Small Cell Lung Cancer 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-phosphorylation to a similar degree and within a similar time frame (e.g., see Figures 1A and 1B above for CS and thapsigargin respectively; tunicamycin data not shown), the suppressive effect of CS on XBP1 splicing is not a global inhibitory effect on other UPR effector arms.
CS Regulation (effect) of XBP1 in arms
1) Confidence 0.20 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.06 Pain Relevance 0
Figure 8 (Panel B) shows that when A549 cells were exposed to CS and subsequently treated with either thapsigargin or tunicamycin, the observed XBP1S levels were significantly diminished, indicating that CS exerts a potent suppressive effect upon XBP1 mRNA splicing (e.g., compare Panel B, lanes 5–12 with Panel A, lanes 5–12).
CS Regulation (effect) of XBP1 mRNA in A549
2) Confidence 0.17 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.09 Pain Relevance 0

General Comments

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