INT244481

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.69
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (ERN1, ATF6) nucleoplasm (ATF6) nuclear envelope (ATF6)
response to stress (ATF6) protein folding (ATF6) signal transduction (ATF6)
Anatomy Link Frequency
groove 1
ERN1 (Homo sapiens)
ATF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 9 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 67 98.00 Very High Very High Very High
Cancer 40 79.40 Quite High
Syndrome 2 78.92 Quite High
Cardiovascular Disease 2 77.36 Quite High
Diabetes Mellitus 2 76.40 Quite High
Death 3 66.04 Quite High
Apoptosis 8 65.44 Quite High
Malignant Neoplastic Disease 20 50.00 Quite Low
Viral Infection 1 31.28 Quite Low
Hypoxia 12 30.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A second mechanism driving activation of these sensor proteins may also involve binding of unfolded protein domains to a peptide-binding groove in both IRE1 and PERK, and possibly ATF6 [17].
IRE1 Binding (binding) of ATF6 in groove
1) Confidence 0.17 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.69 Pain Relevance 0

General Comments

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