INT244497

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.70
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (RNASE1)
RNASE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 9 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 30 92.60 High High
Stress 67 86.64 High High
Lung Cancer 47 78.80 Quite High
Apoptosis 8 78.40 Quite High
Adenocarcinoma 2 65.12 Quite High
Malignant Neoplastic Disease 20 50.00 Quite Low
Cancer 40 5.00 Very Low Very Low Very Low
Hypoxia 12 5.00 Very Low Very Low Very Low
Carcinoma 12 5.00 Very Low Very Low Very Low
Non-small-cell Lung Cancer 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that one or more components of CS can attack the structure of the IRE1 transmembrane protein thereby disabling its ribonuclease function and subsequent splicing of the XBP1 mRNA to its transcriptionally active isoform.
Negative_regulation (disabling) of Gene_expression (function) of ribonuclease
1) Confidence 0.05 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.70 Pain Relevance 0

General Comments

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