INT244511

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.46
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF2S2) RNA binding (EIF2S2) translation factor activity, nucleic acid binding (EIF2S2)
translation (EIF2S2)
Anatomy Link Frequency
lung 1
EIF2S2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 45 49.92 Quite Low
Inflammation 25 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
COX-2 inhibitor 5 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 235 100.00 Very High Very High Very High
Malignant Neoplastic Disease 100 98.88 Very High Very High Very High
Carcinoma 60 97.40 Very High Very High Very High
Cancer 200 94.08 High High
Non-small-cell Lung Cancer 45 93.92 High High
Stress 335 93.28 High High
Small Cell Lung Cancer 40 90.52 High High
Small Cell Lung Carcinoma 10 90.28 High High
Nicotine Addiction 150 79.80 Quite High
Disease 35 64.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figures 1A and 1B also show that during the time period studied (0–4 hours after CS exposure) there were no significant changes in protein levels of total eIF2?
Neg (no) Regulation (changes) of eIF2
1) Confidence 0.37 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.16 Pain Relevance 0
The data indicate a statistically significant difference in expression of phospho-eIF2?
Regulation (difference) of eIF2
2) Confidence 0.23 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.28 Pain Relevance 0
These data implicate dysregulation of the UPR pathway in the pathogenesis of human lung cancers and indicate that phospho-eIF2?
Regulation (dysregulation) of eIF2 in lung associated with lung cancer
3) Confidence 0.23 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.29 Pain Relevance 0
The data indicate a statistically significant difference in expression of phospho-eIF2?
Regulation (difference) of eIF2
4) Confidence 0.23 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.43 Pain Relevance 0
As previously observed for whole CS, there was no alteration in the total level of eIF2?
Neg (no) Regulation (alteration) of eIF2
5) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.29 Pain Relevance 0

General Comments

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